Pathogenic Mechanisms of Atrial Fibrillation in Obesity
Atrial fibrillation (AF) is one of the most common arrhythmias. It reduces quality of life and its duration due to thromboembolic complications. Obesity contributes to the structural and electrical remodeling of atrial myocardium. This leads to occurrence of ectopic foci in the mouths of the pulmona...
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Столичная издательская компания
2016-11-01
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| Series: | Рациональная фармакотерапия в кардиологии |
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| Online Access: | https://www.rpcardio.online/jour/article/view/1340 |
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| author | O. M. Drapkina M. V. Nikolaeva |
| author_facet | O. M. Drapkina M. V. Nikolaeva |
| author_sort | O. M. Drapkina |
| collection | DOAJ |
| description | Atrial fibrillation (AF) is one of the most common arrhythmias. It reduces quality of life and its duration due to thromboembolic complications. Obesity contributes to the structural and electrical remodeling of atrial myocardium. This leads to occurrence of ectopic foci in the mouths of the pulmonary veins and the disruption of normal electrical conduction in the atria. Systemic inflammation, myocardial fibrosis, cardiomyocyte overload by Na+ and Ca2+ ions, accumulation in the cells of unoxidized metabolic products, imbalance of the autonomic regulation are considered as the main mechanisms of arrhythmogenic substrate formation. Hypertension, insulin resistance, and obstructive sleep apnea, associated with obesity, increase the risk of development and progression of the arrhythmia. Study of pathogenetic mechanisms of AF in obesity is necessary to develop new strategies for its prevention and the creation of more effective methods of treatment of these patients. |
| format | Article |
| id | doaj-art-032207f0f2bb466db9babe4b4fda2afe |
| institution | Kabale University |
| issn | 1819-6446 2225-3653 |
| language | English |
| publishDate | 2016-11-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj-art-032207f0f2bb466db9babe4b4fda2afe2025-08-23T10:00:27ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532016-11-0112558258910.20996/1819-6446-2016-12-5-582-5891266Pathogenic Mechanisms of Atrial Fibrillation in ObesityO. M. Drapkina0M. V. Nikolaeva1State Research Center for Preventive Medicine. Petroverigsky per. 10, Moscow, 101990 RussiaI.M. Sechenov First Moscow State Medical University. Trubetskaya ul. 8-2, Moscow, 119991 RussiaAtrial fibrillation (AF) is one of the most common arrhythmias. It reduces quality of life and its duration due to thromboembolic complications. Obesity contributes to the structural and electrical remodeling of atrial myocardium. This leads to occurrence of ectopic foci in the mouths of the pulmonary veins and the disruption of normal electrical conduction in the atria. Systemic inflammation, myocardial fibrosis, cardiomyocyte overload by Na+ and Ca2+ ions, accumulation in the cells of unoxidized metabolic products, imbalance of the autonomic regulation are considered as the main mechanisms of arrhythmogenic substrate formation. Hypertension, insulin resistance, and obstructive sleep apnea, associated with obesity, increase the risk of development and progression of the arrhythmia. Study of pathogenetic mechanisms of AF in obesity is necessary to develop new strategies for its prevention and the creation of more effective methods of treatment of these patients.https://www.rpcardio.online/jour/article/view/1340atrial fibrillationobesityinflammationfibrosis |
| spellingShingle | O. M. Drapkina M. V. Nikolaeva Pathogenic Mechanisms of Atrial Fibrillation in Obesity Рациональная фармакотерапия в кардиологии atrial fibrillation obesity inflammation fibrosis |
| title | Pathogenic Mechanisms of Atrial Fibrillation in Obesity |
| title_full | Pathogenic Mechanisms of Atrial Fibrillation in Obesity |
| title_fullStr | Pathogenic Mechanisms of Atrial Fibrillation in Obesity |
| title_full_unstemmed | Pathogenic Mechanisms of Atrial Fibrillation in Obesity |
| title_short | Pathogenic Mechanisms of Atrial Fibrillation in Obesity |
| title_sort | pathogenic mechanisms of atrial fibrillation in obesity |
| topic | atrial fibrillation obesity inflammation fibrosis |
| url | https://www.rpcardio.online/jour/article/view/1340 |
| work_keys_str_mv | AT omdrapkina pathogenicmechanismsofatrialfibrillationinobesity AT mvnikolaeva pathogenicmechanismsofatrialfibrillationinobesity |