Preliminary exploration of PSMA CAR-T combined with GD2 CAR-T for the treatment of refractory/relapsed gliomas

Preliminary exploration of PSMA CAR-T combined with GD2 CAR-T for the treatment of refractory/relapsed gliomas

Abstract Background This study aimed to investigate the safety and efficacy of fourth-generation combined PSMA and GD2-targeted chimeric antigen receptor (CAR)-T cells in the treatment of refractory/relapsed gliomas. Method This study employed a single-arm design, enrolling patients with confirmed r...

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Bibliographic Details
Main Authors: Jinshan Gu, Jiasheng Li, Yang Xu, Ge Zhang, Jingyi Xie, Rui Jia, Wei Chen, Zhengfeng Lu, Chengwei Chang, Haijun Wen, Lung-ji Chang, Huajuan Ma, Qichun Cai
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Translational Medicine
Subjects:
Refractory/relapsed gliomas
PSMA CAR-T therapy
GD2 CAR-T therapy
Combination therapy
Online Access:https://doi.org/10.1186/s12967-025-06523-1
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