The impact of environmental and host factors on wolbachia density and efficacy as a biological tool
Wolbachia, a bacterium found naturally in some species of Aedes and Culex mosquitoes, has gained significant attention for it's potential in controlling mosquito-borne diseases and suppressing mosquito populations. However, Wolbachia-mediated pathogen blockage, Wolbachia dynamics in field popul...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2023-01-01
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| Series: | Decoding Infection and Transmission |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S294992402300006X |
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| author | John Roberts Padde Qingyu Lu Yuang Long Donghui Zhang Min Hou Lu Chen Zhipeng Xu Lin Chen Minjun Ji |
| author_facet | John Roberts Padde Qingyu Lu Yuang Long Donghui Zhang Min Hou Lu Chen Zhipeng Xu Lin Chen Minjun Ji |
| author_sort | John Roberts Padde |
| collection | DOAJ |
| description | Wolbachia, a bacterium found naturally in some species of Aedes and Culex mosquitoes, has gained significant attention for it's potential in controlling mosquito-borne diseases and suppressing mosquito populations. However, Wolbachia-mediated pathogen blockage, Wolbachia dynamics in field populations and vertical transmission have been reported to be density-dependent. Several factors, including host genetics, diet, temperature, and co-infections can influence Wolbachia titers within its host. The interplay between these factors can have significant influence on the effectiveness of Wolbachia-mediated pathogen blockage and cytoplasmic incompatibility. However, there is a knowledge gap regarding the regulation of Wolbachia density within its host, which could affect its effectiveness as a biocontrol tool. Therefore, this review aims to understand the complex tripartite association between the environment, host, and endosymbiont, and how these relationships are crucial in harnessing the full potential of Wolbachia as a biological tool. Further, we highlight how host, pathogen, and environmental factors influence Wolbachia density and how their interplay can impact CI and WMPB. We further review the strategies adopted to maintain/control Wolbachia densities in field populations. |
| format | Article |
| id | doaj-art-031d11da69934196a7e99f41eb6905f4 |
| institution | OA Journals |
| issn | 2949-9240 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Decoding Infection and Transmission |
| spelling | doaj-art-031d11da69934196a7e99f41eb6905f42025-08-20T02:33:43ZengKeAi Communications Co., Ltd.Decoding Infection and Transmission2949-92402023-01-01110000610.1016/j.dcit.2023.100006The impact of environmental and host factors on wolbachia density and efficacy as a biological toolJohn Roberts Padde0Qingyu Lu1Yuang Long2Donghui Zhang3Min Hou4Lu Chen5Zhipeng Xu6Lin Chen7Minjun Ji8Department of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China; Department of Medical Laboratory Sciences, Muni University, Arua, UgandaProgram of “5+3” Integrative Clinical Medicine, School of First Clinical Medical Science, Nanjing Medical University, Nanjing, Jiangsu, ChinaProgram of “5+3” Integrative Clinical Medicine, School of First Clinical Medical Science, Nanjing Medical University, Nanjing, Jiangsu, ChinaSchool of International Education, Nanjing Medical University, Nanjing, Jiangsu, China; Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, ChinaDepartment of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China; Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, ChinaDepartment of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China; Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, ChinaDepartment of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China; Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, ChinaDepartment of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China; Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China; Corresponding author. Department of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China.Department of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China; Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China; Corresponding author. Department of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China.Wolbachia, a bacterium found naturally in some species of Aedes and Culex mosquitoes, has gained significant attention for it's potential in controlling mosquito-borne diseases and suppressing mosquito populations. However, Wolbachia-mediated pathogen blockage, Wolbachia dynamics in field populations and vertical transmission have been reported to be density-dependent. Several factors, including host genetics, diet, temperature, and co-infections can influence Wolbachia titers within its host. The interplay between these factors can have significant influence on the effectiveness of Wolbachia-mediated pathogen blockage and cytoplasmic incompatibility. However, there is a knowledge gap regarding the regulation of Wolbachia density within its host, which could affect its effectiveness as a biocontrol tool. Therefore, this review aims to understand the complex tripartite association between the environment, host, and endosymbiont, and how these relationships are crucial in harnessing the full potential of Wolbachia as a biological tool. Further, we highlight how host, pathogen, and environmental factors influence Wolbachia density and how their interplay can impact CI and WMPB. We further review the strategies adopted to maintain/control Wolbachia densities in field populations.http://www.sciencedirect.com/science/article/pii/S294992402300006XWolbachia densitiesWolbachia mediated pathogen blockageCytoplasmic incompatibilitySymbiosisEnvironmental factorsHost factors |
| spellingShingle | John Roberts Padde Qingyu Lu Yuang Long Donghui Zhang Min Hou Lu Chen Zhipeng Xu Lin Chen Minjun Ji The impact of environmental and host factors on wolbachia density and efficacy as a biological tool Decoding Infection and Transmission Wolbachia densities Wolbachia mediated pathogen blockage Cytoplasmic incompatibility Symbiosis Environmental factors Host factors |
| title | The impact of environmental and host factors on wolbachia density and efficacy as a biological tool |
| title_full | The impact of environmental and host factors on wolbachia density and efficacy as a biological tool |
| title_fullStr | The impact of environmental and host factors on wolbachia density and efficacy as a biological tool |
| title_full_unstemmed | The impact of environmental and host factors on wolbachia density and efficacy as a biological tool |
| title_short | The impact of environmental and host factors on wolbachia density and efficacy as a biological tool |
| title_sort | impact of environmental and host factors on wolbachia density and efficacy as a biological tool |
| topic | Wolbachia densities Wolbachia mediated pathogen blockage Cytoplasmic incompatibility Symbiosis Environmental factors Host factors |
| url | http://www.sciencedirect.com/science/article/pii/S294992402300006X |
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