Summary of the mechanism of ferroptosis regulated by m6A modification in cancer progression
The most common form of internal RNA modification in eukaryotes is called n6-methyladenosine (m6A) methylation. It has become more and more well-known as a research issue in recent years since it alters RNA metabolism and is involved in numerous biological processes. Currently, m6A alteration offers...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1507171/full |
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| author | Bin Fan Gangxian Chen Shuyi Huang Ying Li Zia Ul Haq Nabil Zuozhang Yang |
| author_facet | Bin Fan Gangxian Chen Shuyi Huang Ying Li Zia Ul Haq Nabil Zuozhang Yang |
| author_sort | Bin Fan |
| collection | DOAJ |
| description | The most common form of internal RNA modification in eukaryotes is called n6-methyladenosine (m6A) methylation. It has become more and more well-known as a research issue in recent years since it alters RNA metabolism and is involved in numerous biological processes. Currently, m6A alteration offers new opportunities in clinical applications and is intimately linked to carcinogenesis. Ferroptosis—a form of iron-dependent, lipid peroxidation-induced regulated cell death—was discovered. In the development of cancer, it has become an important factor. According to newly available data, ferroptosis regulates tumor growth, and cancer exhibits aberrant m6A levels in crucial ferroptosis regulatory components. On the other hand, m6A has multiple roles in the development of tumors, and the relationship between m6A-modified ferroptosis and malignancies is quite intricate. In this review, we first give a thorough review of the regulatory and functional roles of m6A methylation, focusing on the molecular processes of m6A through the regulation of ferroptosis in human cancer progression and metastasis, which are strongly associated to cancer initiation, progression, and drug resistance. Therefore, it is crucial to clarify the relationship between m6A-mediated regulation of ferroptosis in cancer progression, providing a new strategy for cancer treatment with substantial clinical implications. |
| format | Article |
| id | doaj-art-0310c3a70e404d11887d778d7e4b7fb7 |
| institution | OA Journals |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-0310c3a70e404d11887d778d7e4b7fb72025-08-20T02:16:29ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-04-011310.3389/fcell.2025.15071711507171Summary of the mechanism of ferroptosis regulated by m6A modification in cancer progressionBin FanGangxian ChenShuyi HuangYing LiZia Ul Haq NabilZuozhang YangThe most common form of internal RNA modification in eukaryotes is called n6-methyladenosine (m6A) methylation. It has become more and more well-known as a research issue in recent years since it alters RNA metabolism and is involved in numerous biological processes. Currently, m6A alteration offers new opportunities in clinical applications and is intimately linked to carcinogenesis. Ferroptosis—a form of iron-dependent, lipid peroxidation-induced regulated cell death—was discovered. In the development of cancer, it has become an important factor. According to newly available data, ferroptosis regulates tumor growth, and cancer exhibits aberrant m6A levels in crucial ferroptosis regulatory components. On the other hand, m6A has multiple roles in the development of tumors, and the relationship between m6A-modified ferroptosis and malignancies is quite intricate. In this review, we first give a thorough review of the regulatory and functional roles of m6A methylation, focusing on the molecular processes of m6A through the regulation of ferroptosis in human cancer progression and metastasis, which are strongly associated to cancer initiation, progression, and drug resistance. Therefore, it is crucial to clarify the relationship between m6A-mediated regulation of ferroptosis in cancer progression, providing a new strategy for cancer treatment with substantial clinical implications.https://www.frontiersin.org/articles/10.3389/fcell.2025.1507171/fullN6-methyladenosinem6A methyltransferasesm6A demethylasem6A reading proteinferroptosiscancer |
| spellingShingle | Bin Fan Gangxian Chen Shuyi Huang Ying Li Zia Ul Haq Nabil Zuozhang Yang Summary of the mechanism of ferroptosis regulated by m6A modification in cancer progression Frontiers in Cell and Developmental Biology N6-methyladenosine m6A methyltransferases m6A demethylase m6A reading protein ferroptosis cancer |
| title | Summary of the mechanism of ferroptosis regulated by m6A modification in cancer progression |
| title_full | Summary of the mechanism of ferroptosis regulated by m6A modification in cancer progression |
| title_fullStr | Summary of the mechanism of ferroptosis regulated by m6A modification in cancer progression |
| title_full_unstemmed | Summary of the mechanism of ferroptosis regulated by m6A modification in cancer progression |
| title_short | Summary of the mechanism of ferroptosis regulated by m6A modification in cancer progression |
| title_sort | summary of the mechanism of ferroptosis regulated by m6a modification in cancer progression |
| topic | N6-methyladenosine m6A methyltransferases m6A demethylase m6A reading protein ferroptosis cancer |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1507171/full |
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