Myeloid-derived suppressor cells and their role in gynecological malignancies
Myeloid-derived suppressor cells are a heterogeneous population of immature myeloid cells that exhibit immunosuppressive activity (they block the proliferation and activity of both T cells and natural killer cells). In addition to their role in suppressing immune responses, myeloid-derived suppresso...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2018-08-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428318776485 |
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| _version_ | 1849707615776407552 |
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| author | Seiji Mabuchi Eriko Yokoi Naoko Komura Tadashi Kimura |
| author_facet | Seiji Mabuchi Eriko Yokoi Naoko Komura Tadashi Kimura |
| author_sort | Seiji Mabuchi |
| collection | DOAJ |
| description | Myeloid-derived suppressor cells are a heterogeneous population of immature myeloid cells that exhibit immunosuppressive activity (they block the proliferation and activity of both T cells and natural killer cells). In addition to their role in suppressing immune responses, myeloid-derived suppressor cells directly stimulate tumor cell proliferation, metastasis, and angiogenesis. In the area of gynecological cancer, increased numbers of circulating myeloid-derived suppressor cells or tumor-infiltrating myeloid-derived suppressor cells have been detected, and the increased frequencies of myeloid-derived suppressor cells are associated with a poor prognosis. Thus, the successful myeloid-derived suppressor cells depletion may hold the key to maximizing existing anti-cancer therapies and improving the prognosis of gynecological cancer. In this review, we summarize current knowledge regarding myeloid-derived suppressor cells biology, clinical significance of myeloid-derived suppressor cells, and the potential myeloid-derived suppressor cells–targeting strategies in gynecological cancer. |
| format | Article |
| id | doaj-art-030ea88d9170460fbcbdef3e0d44b278 |
| institution | DOAJ |
| issn | 1423-0380 |
| language | English |
| publishDate | 2018-08-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-030ea88d9170460fbcbdef3e0d44b2782025-08-20T03:15:52ZengSAGE PublishingTumor Biology1423-03802018-08-014010.1177/1010428318776485Myeloid-derived suppressor cells and their role in gynecological malignanciesSeiji MabuchiEriko YokoiNaoko KomuraTadashi KimuraMyeloid-derived suppressor cells are a heterogeneous population of immature myeloid cells that exhibit immunosuppressive activity (they block the proliferation and activity of both T cells and natural killer cells). In addition to their role in suppressing immune responses, myeloid-derived suppressor cells directly stimulate tumor cell proliferation, metastasis, and angiogenesis. In the area of gynecological cancer, increased numbers of circulating myeloid-derived suppressor cells or tumor-infiltrating myeloid-derived suppressor cells have been detected, and the increased frequencies of myeloid-derived suppressor cells are associated with a poor prognosis. Thus, the successful myeloid-derived suppressor cells depletion may hold the key to maximizing existing anti-cancer therapies and improving the prognosis of gynecological cancer. In this review, we summarize current knowledge regarding myeloid-derived suppressor cells biology, clinical significance of myeloid-derived suppressor cells, and the potential myeloid-derived suppressor cells–targeting strategies in gynecological cancer.https://doi.org/10.1177/1010428318776485 |
| spellingShingle | Seiji Mabuchi Eriko Yokoi Naoko Komura Tadashi Kimura Myeloid-derived suppressor cells and their role in gynecological malignancies Tumor Biology |
| title | Myeloid-derived suppressor cells and their role in gynecological malignancies |
| title_full | Myeloid-derived suppressor cells and their role in gynecological malignancies |
| title_fullStr | Myeloid-derived suppressor cells and their role in gynecological malignancies |
| title_full_unstemmed | Myeloid-derived suppressor cells and their role in gynecological malignancies |
| title_short | Myeloid-derived suppressor cells and their role in gynecological malignancies |
| title_sort | myeloid derived suppressor cells and their role in gynecological malignancies |
| url | https://doi.org/10.1177/1010428318776485 |
| work_keys_str_mv | AT seijimabuchi myeloidderivedsuppressorcellsandtheirroleingynecologicalmalignancies AT erikoyokoi myeloidderivedsuppressorcellsandtheirroleingynecologicalmalignancies AT naokokomura myeloidderivedsuppressorcellsandtheirroleingynecologicalmalignancies AT tadashikimura myeloidderivedsuppressorcellsandtheirroleingynecologicalmalignancies |