In Vivo Toxicity of Silver Nanoparticles and Silver Ions in Zebrafish (Danio rerio)
The influence of water chemistry on characterised polyvinyl pyrrolidone- (PVP-) coated silver nanoparticles (81 nm) was investigated. NaCl solution series of 100–800 mg L−1 lead to initial and temporal increase in nanoparticles size, but agglomeration was limited. pH variation (5–8) had only minor i...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2012/293784 |
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| author | Katrine Bilberg Mads Bruun Hovgaard Flemming Besenbacher Erik Baatrup |
| author_facet | Katrine Bilberg Mads Bruun Hovgaard Flemming Besenbacher Erik Baatrup |
| author_sort | Katrine Bilberg |
| collection | DOAJ |
| description | The influence of water chemistry on characterised polyvinyl pyrrolidone- (PVP-) coated silver nanoparticles (81 nm) was investigated. NaCl solution series of 100–800 mg L−1 lead to initial and temporal increase in nanoparticles size, but agglomeration was limited. pH variation (5–8) had only minor influence on the hydrodynamic particle size. Acute toxicity of nanosivler to zebrafish (Danio rerio) was investigated in a 48-hour static renewal study and compared with the toxicity of silver ions (AgNO3). The nanosilver and silver ion 48-hour median lethal concentration (LC50) values were 84 μg L−1 and 25 μg L−1, respectively. To investigate exposure-related stress, the fish behaviour was observed visually after 0, 3, 6, 12, 24, 27, 30, and 48 hours of both nanosilver and ionic silver treatments. These observations revealed increased rate of operculum movement and surface respiration after nanosilver exposure, suggesting respiratory toxicity. The present study demonstrates that silver nanoparticles are lethal to zebrafish. |
| format | Article |
| id | doaj-art-030651552459477a8d46f86e6aaec966 |
| institution | OA Journals |
| issn | 1687-8191 1687-8205 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-030651552459477a8d46f86e6aaec9662025-08-20T02:03:25ZengWileyJournal of Toxicology1687-81911687-82052012-01-01201210.1155/2012/293784293784In Vivo Toxicity of Silver Nanoparticles and Silver Ions in Zebrafish (Danio rerio)Katrine Bilberg0Mads Bruun Hovgaard1Flemming Besenbacher2Erik Baatrup3Interdisciplinary Nanoscience Center (iNANO) and Department of Physics and Astronomy, Aarhus University, 8000 Aarhus C, DenmarkInterdisciplinary Nanoscience Center (iNANO) and Department of Physics and Astronomy, Aarhus University, 8000 Aarhus C, DenmarkInterdisciplinary Nanoscience Center (iNANO) and Department of Physics and Astronomy, Aarhus University, 8000 Aarhus C, DenmarkSection of Zoophysiology, Department of Biological Sciences, Aarhus University, C.F. Moellers Allé 3, Building 1131, 8000 Aarhus C, DenmarkThe influence of water chemistry on characterised polyvinyl pyrrolidone- (PVP-) coated silver nanoparticles (81 nm) was investigated. NaCl solution series of 100–800 mg L−1 lead to initial and temporal increase in nanoparticles size, but agglomeration was limited. pH variation (5–8) had only minor influence on the hydrodynamic particle size. Acute toxicity of nanosivler to zebrafish (Danio rerio) was investigated in a 48-hour static renewal study and compared with the toxicity of silver ions (AgNO3). The nanosilver and silver ion 48-hour median lethal concentration (LC50) values were 84 μg L−1 and 25 μg L−1, respectively. To investigate exposure-related stress, the fish behaviour was observed visually after 0, 3, 6, 12, 24, 27, 30, and 48 hours of both nanosilver and ionic silver treatments. These observations revealed increased rate of operculum movement and surface respiration after nanosilver exposure, suggesting respiratory toxicity. The present study demonstrates that silver nanoparticles are lethal to zebrafish.http://dx.doi.org/10.1155/2012/293784 |
| spellingShingle | Katrine Bilberg Mads Bruun Hovgaard Flemming Besenbacher Erik Baatrup In Vivo Toxicity of Silver Nanoparticles and Silver Ions in Zebrafish (Danio rerio) Journal of Toxicology |
| title | In Vivo Toxicity of Silver Nanoparticles and Silver Ions in Zebrafish (Danio rerio) |
| title_full | In Vivo Toxicity of Silver Nanoparticles and Silver Ions in Zebrafish (Danio rerio) |
| title_fullStr | In Vivo Toxicity of Silver Nanoparticles and Silver Ions in Zebrafish (Danio rerio) |
| title_full_unstemmed | In Vivo Toxicity of Silver Nanoparticles and Silver Ions in Zebrafish (Danio rerio) |
| title_short | In Vivo Toxicity of Silver Nanoparticles and Silver Ions in Zebrafish (Danio rerio) |
| title_sort | in vivo toxicity of silver nanoparticles and silver ions in zebrafish danio rerio |
| url | http://dx.doi.org/10.1155/2012/293784 |
| work_keys_str_mv | AT katrinebilberg invivotoxicityofsilvernanoparticlesandsilverionsinzebrafishdaniorerio AT madsbruunhovgaard invivotoxicityofsilvernanoparticlesandsilverionsinzebrafishdaniorerio AT flemmingbesenbacher invivotoxicityofsilvernanoparticlesandsilverionsinzebrafishdaniorerio AT erikbaatrup invivotoxicityofsilvernanoparticlesandsilverionsinzebrafishdaniorerio |