Treatment and Genotypic Characteristics of Patients with Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a significant problem in modern rheumatology, with many patients failing to achieve remission despite the availability of new treatments. A key approach to addressing this problem is pharmacogenetics, which tailors treatments based on genetic characteristics. This study...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
EDP Sciences
2025-01-01
|
| Series: | BIO Web of Conferences |
| Subjects: | |
| Online Access: | https://www.bio-conferences.org/articles/bioconf/pdf/2025/02/bioconf_mblc2024_04030.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832098668970246144 |
|---|---|
| author | Norbutoev Olimjon Akhmedov Khalmurad Abdurakhmanova Nargiza Turaev Ikhtiyor |
| author_facet | Norbutoev Olimjon Akhmedov Khalmurad Abdurakhmanova Nargiza Turaev Ikhtiyor |
| author_sort | Norbutoev Olimjon |
| collection | DOAJ |
| description | Rheumatoid arthritis (RA) is a significant problem in modern rheumatology, with many patients failing to achieve remission despite the availability of new treatments. A key approach to addressing this problem is pharmacogenetics, which tailors treatments based on genetic characteristics. This study focuses on genotyping of MDR1 gene polymorphisms, specifically the C1236T, G2677T, and C3435T isoforms, in patients with RA. The results showed a significant correlation between the C3435T polymorphism and the duration of remission as well as disease activity. Carriers of the TT genotype experienced longer remissions, while patients with the CC genotype exhibited resistance to methotrexate. Based on the genotyping results, individualized treatment regimens were developed, with a focus on methotrexate monotherapy for patients with the TT genotype and alternative treatments for CC carriers. These results highlight the potential of pharmacogenetics to optimize RA treatment and reduce disease activity, leading to better patient outcomes. Further research is recommended to improve personalized RA therapy. |
| format | Article |
| id | doaj-art-0301b5454d4a4d60baa951c40d477ce9 |
| institution | Kabale University |
| issn | 2117-4458 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | BIO Web of Conferences |
| spelling | doaj-art-0301b5454d4a4d60baa951c40d477ce92025-02-05T10:42:42ZengEDP SciencesBIO Web of Conferences2117-44582025-01-011510403010.1051/bioconf/202515104030bioconf_mblc2024_04030Treatment and Genotypic Characteristics of Patients with Rheumatoid ArthritisNorbutoev Olimjon0Akhmedov Khalmurad1Abdurakhmanova Nargiza2Turaev Ikhtiyor3Tashkent Medical AcademyTashkent Medical AcademyTashkent Medical AcademyTashkent Medical AcademyRheumatoid arthritis (RA) is a significant problem in modern rheumatology, with many patients failing to achieve remission despite the availability of new treatments. A key approach to addressing this problem is pharmacogenetics, which tailors treatments based on genetic characteristics. This study focuses on genotyping of MDR1 gene polymorphisms, specifically the C1236T, G2677T, and C3435T isoforms, in patients with RA. The results showed a significant correlation between the C3435T polymorphism and the duration of remission as well as disease activity. Carriers of the TT genotype experienced longer remissions, while patients with the CC genotype exhibited resistance to methotrexate. Based on the genotyping results, individualized treatment regimens were developed, with a focus on methotrexate monotherapy for patients with the TT genotype and alternative treatments for CC carriers. These results highlight the potential of pharmacogenetics to optimize RA treatment and reduce disease activity, leading to better patient outcomes. Further research is recommended to improve personalized RA therapy.https://www.bio-conferences.org/articles/bioconf/pdf/2025/02/bioconf_mblc2024_04030.pdfrheumatoid arthritisisoformhomozygousgenemutationpharmacogeneticsmdr1 polymorphismgenotypingpersonalized medicine |
| spellingShingle | Norbutoev Olimjon Akhmedov Khalmurad Abdurakhmanova Nargiza Turaev Ikhtiyor Treatment and Genotypic Characteristics of Patients with Rheumatoid Arthritis BIO Web of Conferences rheumatoid arthritis isoform homozygous gene mutation pharmacogenetics mdr1 polymorphism genotyping personalized medicine |
| title | Treatment and Genotypic Characteristics of Patients with Rheumatoid Arthritis |
| title_full | Treatment and Genotypic Characteristics of Patients with Rheumatoid Arthritis |
| title_fullStr | Treatment and Genotypic Characteristics of Patients with Rheumatoid Arthritis |
| title_full_unstemmed | Treatment and Genotypic Characteristics of Patients with Rheumatoid Arthritis |
| title_short | Treatment and Genotypic Characteristics of Patients with Rheumatoid Arthritis |
| title_sort | treatment and genotypic characteristics of patients with rheumatoid arthritis |
| topic | rheumatoid arthritis isoform homozygous gene mutation pharmacogenetics mdr1 polymorphism genotyping personalized medicine |
| url | https://www.bio-conferences.org/articles/bioconf/pdf/2025/02/bioconf_mblc2024_04030.pdf |
| work_keys_str_mv | AT norbutoevolimjon treatmentandgenotypiccharacteristicsofpatientswithrheumatoidarthritis AT akhmedovkhalmurad treatmentandgenotypiccharacteristicsofpatientswithrheumatoidarthritis AT abdurakhmanovanargiza treatmentandgenotypiccharacteristicsofpatientswithrheumatoidarthritis AT turaevikhtiyor treatmentandgenotypiccharacteristicsofpatientswithrheumatoidarthritis |