Urinary KIM-1 and AQP-1 in patients with clear renal cell carcinoma: Potential noninvasive biomarkers
Background/Aim. Kidney injury molecule-1 (KIM-1) and aquaporin-1 (AQP-1) are potential early urinary biomarkers of clear renal cell carcinoma (cRCC). The aim of this study was to ascertain relationship between the urine concentrations KIM-1 and AQP-1 with tumor size, grade, pT stage and typ...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2016-01-01
|
| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2016/0042-84501600006M.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Background/Aim. Kidney injury molecule-1 (KIM-1) and aquaporin-1 (AQP-1) are
potential early urinary biomarkers of clear renal cell carcinoma (cRCC). The
aim of this study was to ascertain relationship between the urine
concentrations KIM-1 and AQP-1 with tumor size, grade, pT stage and type of
operation (radical or partial nephrectomy) in patients with cRCC. Methods.
Urinary concentrations of urinary KIM-1 (uKIM-1) and urinary AQP-1 (uAQP-1)
were determined by commercially available ELISA kits. The analysis included
40 patients undergoing partial or radical nephrectomy for cRCC and 40 age-
and sex-matched healthy adult volunteers. Results. The median preoperative
concentrations of KIM-1 in the cRCC group [0.724 ± 1.120 ng/mg urinary
creatinine (Ucr)] were significantly greater compared with controls (healthy
volunteers) (0.210 ± 0.082 ng/mgUcr) (p = 0.0227). Postoperatively, uKIM-1
concentration decreased significantly to control values (0.177 ± 0.099
ng/mgUcr vs 0.210 ± 0.082 ng/mgUcr, respectively). The size, grade and stage
of tumor were correlated positively with preoperative uKIM-1 concentrations.
Contrary to these results, concentrations of uAQP-1 in the cRCC group were
significantly lower (0.111 ± 0.092 ng/mgUcr) compared with the control group
(0.202 ± 0.078 ng/mgUcr) (p = 0.0014). Postoperatively, the concentrations
of uAQP-1 increased progressively up to control values, approximately. We
find no significant correlation between preoperative uAQP-1 concentrations
and tumor size, grade and stage. Conclusion. uKIM-1 was found to be a
reliable diagnostic marker of cRCC, based on its significantly increased
values before and decreased values after the nephrectomy. [Projekat
Ministarstva nauke Republike Srbije, br. III41018] |
|---|---|
| ISSN: | 0042-8450 2406-0720 |