Dietary factors and risk for endometriosis: a Mendelian randomization analysis
Abstract Aims Observational studies have reported an association between dietary factors and endometriosis, but the causality remains unknown. The study aimed to investigate the potential causal association between dietary factors and endometriosis using Mendelian randomization (MR). Methods We perf...
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2025-07-01
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| Online Access: | https://doi.org/10.1186/s12986-025-00970-9 |
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| author | Xia Zhang Qiaomei Zheng Lihong Chen |
| author_facet | Xia Zhang Qiaomei Zheng Lihong Chen |
| author_sort | Xia Zhang |
| collection | DOAJ |
| description | Abstract Aims Observational studies have reported an association between dietary factors and endometriosis, but the causality remains unknown. The study aimed to investigate the potential causal association between dietary factors and endometriosis using Mendelian randomization (MR). Methods We performed a two-sample MR analysis to investigate the effects of 18 diet-related exposure factors (alcoholic drinks per week, alcohol intake frequency, processed meat intake, poultry intake, beef intake, non-oily fish intake, oily fish intake, pork intake, lamb/mutton intake, bread intake, cheese intake, cooked vegetable intake, tea intake, fresh fruit intake, cereal intake, salad/raw vegetable intake, coffee intake, dried fruit intake) on the risk of endometriosis using summary statistics from the genome-wide association study (GWAS). The inverse variance weighted (IVW) method was used to deduce the causal association between dietary factors and endometriosis, and sensitivity analyses were further performed. Results Processed meat intake (OR = 0.550; 95%CI:0.314–0.965; p = 0.037) and salad / raw vegetable intake (OR = 0.346; 95%CI:0.127–0.943; p = 0.038) were discovered as protective factors for endometriosis. Heterogeneity test revealed no significant heterogeneity (processed meat intake: pIVW=0.607, pMR−Egger=0.548; salad / raw vegetable intake: pIVW=0.678, pMR−Egger=0.620). MR-Egger regression test didn’t support any evidence for horizontal pleiotropy (processed meat intake: p for intercept = 0.865; salad / raw vegetable intake: p for intercept = 0.725). No causal relationship was found between other dietary intakes and endometriosis. Conclusion These findings suggest that processed meat intake and salad/raw vegetable intake are associated with a decreased risk of endometriosis, but further investigation is required. |
| format | Article |
| id | doaj-art-02e835f9ae1b4df99e1f3f35e9872f53 |
| institution | DOAJ |
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| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
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| series | Nutrition & Metabolism |
| spelling | doaj-art-02e835f9ae1b4df99e1f3f35e9872f532025-08-20T03:04:26ZengBMCNutrition & Metabolism1743-70752025-07-0122111310.1186/s12986-025-00970-9Dietary factors and risk for endometriosis: a Mendelian randomization analysisXia Zhang0Qiaomei Zheng1Lihong Chen2Department of Obstetrics and Gynecology, the First Affiliated Hospital, Fujian Medical UniversityDepartment of Obstetrics and Gynecology, the First Affiliated Hospital, Fujian Medical UniversityDepartment of Obstetrics and Gynecology, the First Affiliated Hospital, Fujian Medical UniversityAbstract Aims Observational studies have reported an association between dietary factors and endometriosis, but the causality remains unknown. The study aimed to investigate the potential causal association between dietary factors and endometriosis using Mendelian randomization (MR). Methods We performed a two-sample MR analysis to investigate the effects of 18 diet-related exposure factors (alcoholic drinks per week, alcohol intake frequency, processed meat intake, poultry intake, beef intake, non-oily fish intake, oily fish intake, pork intake, lamb/mutton intake, bread intake, cheese intake, cooked vegetable intake, tea intake, fresh fruit intake, cereal intake, salad/raw vegetable intake, coffee intake, dried fruit intake) on the risk of endometriosis using summary statistics from the genome-wide association study (GWAS). The inverse variance weighted (IVW) method was used to deduce the causal association between dietary factors and endometriosis, and sensitivity analyses were further performed. Results Processed meat intake (OR = 0.550; 95%CI:0.314–0.965; p = 0.037) and salad / raw vegetable intake (OR = 0.346; 95%CI:0.127–0.943; p = 0.038) were discovered as protective factors for endometriosis. Heterogeneity test revealed no significant heterogeneity (processed meat intake: pIVW=0.607, pMR−Egger=0.548; salad / raw vegetable intake: pIVW=0.678, pMR−Egger=0.620). MR-Egger regression test didn’t support any evidence for horizontal pleiotropy (processed meat intake: p for intercept = 0.865; salad / raw vegetable intake: p for intercept = 0.725). No causal relationship was found between other dietary intakes and endometriosis. Conclusion These findings suggest that processed meat intake and salad/raw vegetable intake are associated with a decreased risk of endometriosis, but further investigation is required.https://doi.org/10.1186/s12986-025-00970-9Dietary intakeEndometriosisMendelian randomizationCausal associationProcessed meat intakeSalad/raw vegetable intake |
| spellingShingle | Xia Zhang Qiaomei Zheng Lihong Chen Dietary factors and risk for endometriosis: a Mendelian randomization analysis Nutrition & Metabolism Dietary intake Endometriosis Mendelian randomization Causal association Processed meat intake Salad/raw vegetable intake |
| title | Dietary factors and risk for endometriosis: a Mendelian randomization analysis |
| title_full | Dietary factors and risk for endometriosis: a Mendelian randomization analysis |
| title_fullStr | Dietary factors and risk for endometriosis: a Mendelian randomization analysis |
| title_full_unstemmed | Dietary factors and risk for endometriosis: a Mendelian randomization analysis |
| title_short | Dietary factors and risk for endometriosis: a Mendelian randomization analysis |
| title_sort | dietary factors and risk for endometriosis a mendelian randomization analysis |
| topic | Dietary intake Endometriosis Mendelian randomization Causal association Processed meat intake Salad/raw vegetable intake |
| url | https://doi.org/10.1186/s12986-025-00970-9 |
| work_keys_str_mv | AT xiazhang dietaryfactorsandriskforendometriosisamendelianrandomizationanalysis AT qiaomeizheng dietaryfactorsandriskforendometriosisamendelianrandomizationanalysis AT lihongchen dietaryfactorsandriskforendometriosisamendelianrandomizationanalysis |