Cathepsin B induces kidney diseases through different types of programmed cell death
Cathepsin B (CTSB), a key cysteine protease, plays essential roles in physiological and pathological processes. As research progresses, interest in how CTSB triggers different types of programmed cell death (PCD) to induce the onset and development of diseases is increasing. Several recent studies s...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1535313/full |
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| author | Yunlong Zhao Yunlong Zhao Yunlong Zhao Yong Zhuang Yong Zhuang Yong Zhuang Jie Shi Jie Shi Jie Shi Haojun Fan Haojun Fan Haojun Fan Qi Lv Qi Lv Qi Lv Xiaoqin Guo Xiaoqin Guo Xiaoqin Guo |
| author_facet | Yunlong Zhao Yunlong Zhao Yunlong Zhao Yong Zhuang Yong Zhuang Yong Zhuang Jie Shi Jie Shi Jie Shi Haojun Fan Haojun Fan Haojun Fan Qi Lv Qi Lv Qi Lv Xiaoqin Guo Xiaoqin Guo Xiaoqin Guo |
| author_sort | Yunlong Zhao |
| collection | DOAJ |
| description | Cathepsin B (CTSB), a key cysteine protease, plays essential roles in physiological and pathological processes. As research progresses, interest in how CTSB triggers different types of programmed cell death (PCD) to induce the onset and development of diseases is increasing. Several recent studies suggest that different types of PCD mediated by CTSB play key roles in kidney diseases. In this review, we outline the fundamental mechanisms by which CTSB triggers different types of PCD in several kidney diseases and discuss the function of CTSB in various segments of the kidney. Moreover, we explore the possibilities and prospects of using CTSB as a therapeutic target for kidney diseases. |
| format | Article |
| id | doaj-art-02e52e5428bf4e4996343ab47d76dca8 |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-02e52e5428bf4e4996343ab47d76dca82025-08-20T01:57:19ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-03-011610.3389/fimmu.2025.15353131535313Cathepsin B induces kidney diseases through different types of programmed cell deathYunlong Zhao0Yunlong Zhao1Yunlong Zhao2Yong Zhuang3Yong Zhuang4Yong Zhuang5Jie Shi6Jie Shi7Jie Shi8Haojun Fan9Haojun Fan10Haojun Fan11Qi Lv12Qi Lv13Qi Lv14Xiaoqin Guo15Xiaoqin Guo16Xiaoqin Guo17Institute of Disaster and Emergency Medicine, Tianjin University, Tianjin, ChinaKey Laboratory for Disaster Medicine Technology, Tianjin University, Tianjin, ChinaWenzhou Safety (Emergency) Institute, Tianjin University, Wenzhou, ChinaInstitute of Disaster and Emergency Medicine, Tianjin University, Tianjin, ChinaKey Laboratory for Disaster Medicine Technology, Tianjin University, Tianjin, ChinaWenzhou Safety (Emergency) Institute, Tianjin University, Wenzhou, ChinaInstitute of Disaster and Emergency Medicine, Tianjin University, Tianjin, ChinaKey Laboratory for Disaster Medicine Technology, Tianjin University, Tianjin, ChinaWenzhou Safety (Emergency) Institute, Tianjin University, Wenzhou, ChinaInstitute of Disaster and Emergency Medicine, Tianjin University, Tianjin, ChinaKey Laboratory for Disaster Medicine Technology, Tianjin University, Tianjin, ChinaWenzhou Safety (Emergency) Institute, Tianjin University, Wenzhou, ChinaInstitute of Disaster and Emergency Medicine, Tianjin University, Tianjin, ChinaKey Laboratory for Disaster Medicine Technology, Tianjin University, Tianjin, ChinaWenzhou Safety (Emergency) Institute, Tianjin University, Wenzhou, ChinaInstitute of Disaster and Emergency Medicine, Tianjin University, Tianjin, ChinaKey Laboratory for Disaster Medicine Technology, Tianjin University, Tianjin, ChinaWenzhou Safety (Emergency) Institute, Tianjin University, Wenzhou, ChinaCathepsin B (CTSB), a key cysteine protease, plays essential roles in physiological and pathological processes. As research progresses, interest in how CTSB triggers different types of programmed cell death (PCD) to induce the onset and development of diseases is increasing. Several recent studies suggest that different types of PCD mediated by CTSB play key roles in kidney diseases. In this review, we outline the fundamental mechanisms by which CTSB triggers different types of PCD in several kidney diseases and discuss the function of CTSB in various segments of the kidney. Moreover, we explore the possibilities and prospects of using CTSB as a therapeutic target for kidney diseases.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1535313/fullcathepsin Bkidney diseaseprogrammed cell deathmechanismtherapeutic target |
| spellingShingle | Yunlong Zhao Yunlong Zhao Yunlong Zhao Yong Zhuang Yong Zhuang Yong Zhuang Jie Shi Jie Shi Jie Shi Haojun Fan Haojun Fan Haojun Fan Qi Lv Qi Lv Qi Lv Xiaoqin Guo Xiaoqin Guo Xiaoqin Guo Cathepsin B induces kidney diseases through different types of programmed cell death Frontiers in Immunology cathepsin B kidney disease programmed cell death mechanism therapeutic target |
| title | Cathepsin B induces kidney diseases through different types of programmed cell death |
| title_full | Cathepsin B induces kidney diseases through different types of programmed cell death |
| title_fullStr | Cathepsin B induces kidney diseases through different types of programmed cell death |
| title_full_unstemmed | Cathepsin B induces kidney diseases through different types of programmed cell death |
| title_short | Cathepsin B induces kidney diseases through different types of programmed cell death |
| title_sort | cathepsin b induces kidney diseases through different types of programmed cell death |
| topic | cathepsin B kidney disease programmed cell death mechanism therapeutic target |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1535313/full |
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