Hemodialysis Treatment for High-Dose Quetiapine Fumarate Poisoning: A Case Report
Introduction: Quetiapine is a new atypical antipsychotic with minor side effects. There have been few reports of rhabdomyolysis and acute kidney injury associated with quetiapine overdose. Case Presentation: This article presents a rare case of high-dose quetiapine poisoning that improved...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2025-03-01
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| Series: | Case Reports in Nephrology and Dialysis |
| Online Access: | https://karger.com/article/doi/10.1159/000545048 |
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| author | Jiaoyang Li Zhiqin Chen Shuran Qian Xuemei Liu |
| author_facet | Jiaoyang Li Zhiqin Chen Shuran Qian Xuemei Liu |
| author_sort | Jiaoyang Li |
| collection | DOAJ |
| description |
Introduction: Quetiapine is a new atypical antipsychotic with minor side effects. There have been few reports of rhabdomyolysis and acute kidney injury associated with quetiapine overdose. Case Presentation: This article presents a rare case of high-dose quetiapine poisoning that improved after treatment. The patient experienced rhabdomyolysis, acute kidney injury, long QT syndrome, and peripheral neuropathy, all of which are typical complications of quetiapine poisoning. Moreover, a kidney biopsy verified the patient’s acute tubulointerstitial injury, and immunohistochemical staining demonstrated that myoglobin cast nephropathy was the cause of the injury. This patient’s kidney function and associated complications recovered after receiving hemodialysis, rehabilitation, heart rate regulation, and further symptomatic interventions. Consequently, hemodialysis was discontinued. Conclusion: Our case showed that myoglobin cast nephropathy was the cause of the acute kidney injury associated with quetiapine poisoning. The kidney biopsy is essential for accurate diagnosis and treatment. |
| format | Article |
| id | doaj-art-02d76c714dbd41abb606d67d32004e70 |
| institution | OA Journals |
| issn | 2296-9705 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Nephrology and Dialysis |
| spelling | doaj-art-02d76c714dbd41abb606d67d32004e702025-08-20T02:31:56ZengKarger PublishersCase Reports in Nephrology and Dialysis2296-97052025-03-01151414610.1159/000545048Hemodialysis Treatment for High-Dose Quetiapine Fumarate Poisoning: A Case ReportJiaoyang LiZhiqin ChenShuran QianXuemei Liu Introduction: Quetiapine is a new atypical antipsychotic with minor side effects. There have been few reports of rhabdomyolysis and acute kidney injury associated with quetiapine overdose. Case Presentation: This article presents a rare case of high-dose quetiapine poisoning that improved after treatment. The patient experienced rhabdomyolysis, acute kidney injury, long QT syndrome, and peripheral neuropathy, all of which are typical complications of quetiapine poisoning. Moreover, a kidney biopsy verified the patient’s acute tubulointerstitial injury, and immunohistochemical staining demonstrated that myoglobin cast nephropathy was the cause of the injury. This patient’s kidney function and associated complications recovered after receiving hemodialysis, rehabilitation, heart rate regulation, and further symptomatic interventions. Consequently, hemodialysis was discontinued. Conclusion: Our case showed that myoglobin cast nephropathy was the cause of the acute kidney injury associated with quetiapine poisoning. The kidney biopsy is essential for accurate diagnosis and treatment. https://karger.com/article/doi/10.1159/000545048 |
| spellingShingle | Jiaoyang Li Zhiqin Chen Shuran Qian Xuemei Liu Hemodialysis Treatment for High-Dose Quetiapine Fumarate Poisoning: A Case Report Case Reports in Nephrology and Dialysis |
| title | Hemodialysis Treatment for High-Dose Quetiapine Fumarate Poisoning: A Case Report |
| title_full | Hemodialysis Treatment for High-Dose Quetiapine Fumarate Poisoning: A Case Report |
| title_fullStr | Hemodialysis Treatment for High-Dose Quetiapine Fumarate Poisoning: A Case Report |
| title_full_unstemmed | Hemodialysis Treatment for High-Dose Quetiapine Fumarate Poisoning: A Case Report |
| title_short | Hemodialysis Treatment for High-Dose Quetiapine Fumarate Poisoning: A Case Report |
| title_sort | hemodialysis treatment for high dose quetiapine fumarate poisoning a case report |
| url | https://karger.com/article/doi/10.1159/000545048 |
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