LC-MS/MS-Based Concurrent Quantification of Cannabidiol and Melatonin in Mouse Plasma to Elucidate Complex PK Interactions

LC-MS/MS-Based Concurrent Quantification of Cannabidiol and Melatonin in Mouse Plasma to Elucidate Complex PK Interactions

<b>Objective:</b> This study aimed to develop a quantitative analytical method for the simultaneous determination of cannabidiol (CBD) and melatonin (MT) in mouse plasma using the protein precipitation method coupled with LC-MS/MS. Additionally, this study sought to investigate the impac...

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Bibliographic Details
Main Authors: Mengran Wang, Wenpeng Zhang, Xia Wu, Lingchao Wang, Cong Li, Chunyan Liu, Xiaomei Zhuang
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Pharmaceutics
Subjects:
melatonin
cannabidiol
LC-MS/MS
pharmacokinetics
complex drug–drug interactions
Online Access:https://www.mdpi.com/1999-4923/16/12/1511
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