Graphene Oxide as a Nanocarrier for Controlled Loading and Targeted Delivery of Typhonium giganteum Drugs
In this study, Typhonium giganteum containing dual-function nanofibers composed of poly(butylene carbonate), polylactic acid, and graphene oxide (PBC/PLA/GO) were successfully fabricated by electrospinning. The results from thermogravimetric analysis (TG), differential scanning calorimetry (DSC), an...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2018/6325870 |
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| author | Xiaohua Gu Rui Cao Fu Li Yan Li Hongge Jia Hui Yu |
| author_facet | Xiaohua Gu Rui Cao Fu Li Yan Li Hongge Jia Hui Yu |
| author_sort | Xiaohua Gu |
| collection | DOAJ |
| description | In this study, Typhonium giganteum containing dual-function nanofibers composed of poly(butylene carbonate), polylactic acid, and graphene oxide (PBC/PLA/GO) were successfully fabricated by electrospinning. The results from thermogravimetric analysis (TG), differential scanning calorimetry (DSC), and Fourier-transform infrared spectroscopy (FTIR) indicate that no interactions occurred between PBC and PLA. The nanofiber microstructure upon which graphene oxide was evenly distributed was studied by scanning electron microscopy (SEM) and showed good silk properties. The nanofibers can be used as a drug carrier since loaded Typhonium giganteum fibers possess excellent biocompatibility. Such nanofibers are effective in inhibiting the proliferation of A549 lung cancer cells, and thus they have potential for replacing chemotherapy-based treatments of lung cancer. In addition, the PBC/PLA/GO nanofibers degrade in physiological and natural environments, which is an important feature when engineering tissues and environment-friendly materials. |
| format | Article |
| id | doaj-art-02d289616ff641f3915656fd5b38f616 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-02d289616ff641f3915656fd5b38f6162025-02-03T01:24:26ZengWileyJournal of Chemistry2090-90632090-90712018-01-01201810.1155/2018/63258706325870Graphene Oxide as a Nanocarrier for Controlled Loading and Targeted Delivery of Typhonium giganteum DrugsXiaohua Gu0Rui Cao1Fu Li2Yan Li3Hongge Jia4Hui Yu5College of Materials Science and Engineering, Qiqihar University, Qiqihar 161006, ChinaCollege of Materials Science and Engineering, Qiqihar University, Qiqihar 161006, ChinaCollege of Materials Science and Engineering, Qiqihar University, Qiqihar 161006, ChinaCollege of Materials Science and Engineering, Qiqihar University, Qiqihar 161006, ChinaCollege of Materials Science and Engineering, Qiqihar University, Qiqihar 161006, ChinaCollege of Textile Materials and Engineering, Wuyi University, Jiangmen 529000, ChinaIn this study, Typhonium giganteum containing dual-function nanofibers composed of poly(butylene carbonate), polylactic acid, and graphene oxide (PBC/PLA/GO) were successfully fabricated by electrospinning. The results from thermogravimetric analysis (TG), differential scanning calorimetry (DSC), and Fourier-transform infrared spectroscopy (FTIR) indicate that no interactions occurred between PBC and PLA. The nanofiber microstructure upon which graphene oxide was evenly distributed was studied by scanning electron microscopy (SEM) and showed good silk properties. The nanofibers can be used as a drug carrier since loaded Typhonium giganteum fibers possess excellent biocompatibility. Such nanofibers are effective in inhibiting the proliferation of A549 lung cancer cells, and thus they have potential for replacing chemotherapy-based treatments of lung cancer. In addition, the PBC/PLA/GO nanofibers degrade in physiological and natural environments, which is an important feature when engineering tissues and environment-friendly materials.http://dx.doi.org/10.1155/2018/6325870 |
| spellingShingle | Xiaohua Gu Rui Cao Fu Li Yan Li Hongge Jia Hui Yu Graphene Oxide as a Nanocarrier for Controlled Loading and Targeted Delivery of Typhonium giganteum Drugs Journal of Chemistry |
| title | Graphene Oxide as a Nanocarrier for Controlled Loading and Targeted Delivery of Typhonium giganteum Drugs |
| title_full | Graphene Oxide as a Nanocarrier for Controlled Loading and Targeted Delivery of Typhonium giganteum Drugs |
| title_fullStr | Graphene Oxide as a Nanocarrier for Controlled Loading and Targeted Delivery of Typhonium giganteum Drugs |
| title_full_unstemmed | Graphene Oxide as a Nanocarrier for Controlled Loading and Targeted Delivery of Typhonium giganteum Drugs |
| title_short | Graphene Oxide as a Nanocarrier for Controlled Loading and Targeted Delivery of Typhonium giganteum Drugs |
| title_sort | graphene oxide as a nanocarrier for controlled loading and targeted delivery of typhonium giganteum drugs |
| url | http://dx.doi.org/10.1155/2018/6325870 |
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