Oxidative Stress Defense Module in Lung Cancers: Molecular Pathways and Therapeutic Approaches
The regulation of oxidative stress is an effective strategy for treating cancers. Therapeutic strategies for modulating an undesirable redox balance against cancers have included the enhancement of oxidative components, reducing the action of antioxidant systems, and the combined application of radi...
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MDPI AG
2025-07-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/14/7/857 |
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| author | Eunsun Lee Jeong Hee Hong |
| author_facet | Eunsun Lee Jeong Hee Hong |
| author_sort | Eunsun Lee |
| collection | DOAJ |
| description | The regulation of oxidative stress is an effective strategy for treating cancers. Therapeutic strategies for modulating an undesirable redox balance against cancers have included the enhancement of oxidative components, reducing the action of antioxidant systems, and the combined application of radiation and redox-modulating drugs. A precise understanding of redox regulation is required to treat different kinds of cancer. This review focuses on the redox regulation and oxidative stress defense systems of lung cancers. Thus, we highlighted several enzymatic antioxidant components, such as superoxide dismutase, catalase, heme oxygenase-1, peroxiredoxin, glutaredoxin, thioredoxin, thioredoxin reductase, glutathione peroxidase, and antioxidant components, including glutathione, nuclear factor erythroid 2–related factor 2, 8-oxo-7,8-dihydro-2′-deoxyguanosine, and mitochondrial citrate carrier SLC25A1, based on PubMed and Scopus-indexed literature. Understanding the oxidative stress defense system in lung cancer would be beneficial for developing and expanding therapeutic strategies, such as drug development, drug design, and advanced delivery platforms. |
| format | Article |
| id | doaj-art-02d0f51fccbb414db2b18aab4eebc630 |
| institution | DOAJ |
| issn | 2076-3921 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj-art-02d0f51fccbb414db2b18aab4eebc6302025-08-20T02:45:53ZengMDPI AGAntioxidants2076-39212025-07-0114785710.3390/antiox14070857Oxidative Stress Defense Module in Lung Cancers: Molecular Pathways and Therapeutic ApproachesEunsun Lee0Jeong Hee Hong1Department of Physiology, College of Medicine, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, 155 Getbeolro, Yeonsu-gu, Incheon 21999, Republic of KoreaDepartment of Physiology, College of Medicine, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, 155 Getbeolro, Yeonsu-gu, Incheon 21999, Republic of KoreaThe regulation of oxidative stress is an effective strategy for treating cancers. Therapeutic strategies for modulating an undesirable redox balance against cancers have included the enhancement of oxidative components, reducing the action of antioxidant systems, and the combined application of radiation and redox-modulating drugs. A precise understanding of redox regulation is required to treat different kinds of cancer. This review focuses on the redox regulation and oxidative stress defense systems of lung cancers. Thus, we highlighted several enzymatic antioxidant components, such as superoxide dismutase, catalase, heme oxygenase-1, peroxiredoxin, glutaredoxin, thioredoxin, thioredoxin reductase, glutathione peroxidase, and antioxidant components, including glutathione, nuclear factor erythroid 2–related factor 2, 8-oxo-7,8-dihydro-2′-deoxyguanosine, and mitochondrial citrate carrier SLC25A1, based on PubMed and Scopus-indexed literature. Understanding the oxidative stress defense system in lung cancer would be beneficial for developing and expanding therapeutic strategies, such as drug development, drug design, and advanced delivery platforms.https://www.mdpi.com/2076-3921/14/7/857oxidative stressredox regulationoxidative stress defense systemlung cancer |
| spellingShingle | Eunsun Lee Jeong Hee Hong Oxidative Stress Defense Module in Lung Cancers: Molecular Pathways and Therapeutic Approaches Antioxidants oxidative stress redox regulation oxidative stress defense system lung cancer |
| title | Oxidative Stress Defense Module in Lung Cancers: Molecular Pathways and Therapeutic Approaches |
| title_full | Oxidative Stress Defense Module in Lung Cancers: Molecular Pathways and Therapeutic Approaches |
| title_fullStr | Oxidative Stress Defense Module in Lung Cancers: Molecular Pathways and Therapeutic Approaches |
| title_full_unstemmed | Oxidative Stress Defense Module in Lung Cancers: Molecular Pathways and Therapeutic Approaches |
| title_short | Oxidative Stress Defense Module in Lung Cancers: Molecular Pathways and Therapeutic Approaches |
| title_sort | oxidative stress defense module in lung cancers molecular pathways and therapeutic approaches |
| topic | oxidative stress redox regulation oxidative stress defense system lung cancer |
| url | https://www.mdpi.com/2076-3921/14/7/857 |
| work_keys_str_mv | AT eunsunlee oxidativestressdefensemoduleinlungcancersmolecularpathwaysandtherapeuticapproaches AT jeongheehong oxidativestressdefensemoduleinlungcancersmolecularpathwaysandtherapeuticapproaches |