Prognostic value of red blood cell distribution width (RDW) in patients with multi-vessel coronary artery disease.
INTRODUCTION: Coronary artery disease (CAD) is one of the most common cardiovascular problems and a frequent cause of death worldwide. Multi-vessel CAD is an advanced condition in which the lumen of ≥ 3 epicardial arteries becomes narrowed due to atherosclerosis. The red blood cell distribution widt...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Via Medica
2025-12-01
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| Series: | Folia Cardiologica |
| Subjects: | |
| Online Access: | https://journals.viamedica.pl/folia_cardiologica/article/view/103206 |
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| Summary: | INTRODUCTION: Coronary artery disease (CAD) is one of the most common cardiovascular problems and a frequent cause of death worldwide. Multi-vessel CAD is an advanced condition in which the lumen of ≥ 3 epicardial arteries becomes narrowed due to atherosclerosis. The red blood cell distribution width (RDW) is a simple parameter of blood count, expressing the anisocytosis of erythrocytes. Higher value of RDW may be related with adverse outcomes in patients with cardiovascular diseases. We examined the association between RDW and the risk of all-cause mortality and adverse cardiovascular outcomes in patients with multi-vessel CAD. MATERIAL AND METHODS: The study was performed on 112 patients with multi-vessel CAD hospitalized in the Cardiology Department of the Central Clinical Hospital of the Medical University in Lodz. Demographic and clinical characteristics were obtained, and 12-month follow-up was performed. RESULTS: Seventy-five per cent of patients with multi-vessel CAD were men. The average age was 68.2 years, and the average BMI was 29.3 kg/m². The most common comorbidities were hypercholesterolemia (94%), hypertension (91%), smoking (71%), and diabetes (45%). Most patients presented severe symptoms of angina pectoris in CCS class III (60%) and class IV (10%). The mean RDW was 13.5% (12.8–14.6). In patients with multi-vessel CAD, there was no correlation between RDW and CCS class (R = 0.05, p = 0.6296), left ventricular ejection fraction (R = 0.03, p= 0.7457), death rate in one-year follow-up (p = 0.1438), and myocardial infarction (p = 0.6592). Patients who experienced acute or decompensated heart failure (HF) had higher RDW (p = 0.0420). CONCLUSIONS: Contrary to the data available in the literature regarding patients with stable CAD, in the group of patients with multi-vessel CAD, no impact of RDW on mortality or myocardial infarction was observed. However, in the analysis, higher RDW was demonstrated to be an independent predictor for a new onset of HF or chronic HF decompensation in patients with multi-vessel CAD. |
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| ISSN: | 2353-7752 2353-7760 |