Unveiling promising targets in gastric cancer therapy: A comprehensive review
Gastric cancer (GC) poses a significant global health challenge, ranking fifth in incidence and third in mortality among all malignancies worldwide. Its insidious onset, aggressive growth, proclivity for metastasis, and limited treatment options have contributed to its high fatality rate. Traditiona...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-09-01
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| Series: | Molecular Therapy: Oncology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950329924000997 |
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| author | Wenke Li Jing Wei Mo Cheng Ming Liu |
| author_facet | Wenke Li Jing Wei Mo Cheng Ming Liu |
| author_sort | Wenke Li |
| collection | DOAJ |
| description | Gastric cancer (GC) poses a significant global health challenge, ranking fifth in incidence and third in mortality among all malignancies worldwide. Its insidious onset, aggressive growth, proclivity for metastasis, and limited treatment options have contributed to its high fatality rate. Traditional approaches for GC treatment primarily involve surgery and chemotherapy. However, there is growing interest in targeted therapies and immunotherapies. This comprehensive review highlights recent advancements in GC targeted therapy and immunotherapy. It delves into the mechanisms of various strategies, underscoring their potential in GC treatment. Additionally, the review evaluates the efficacy and safety of relevant clinical trials. Despite the benefits observed in numerous advanced GC patients with targeted therapies and immunotherapies, challenges persist. We discuss pertinent strategies to overcome these challenges, thereby providing a solid foundation for enhancing the clinical effectiveness of targeted therapies and immunotherapies. |
| format | Article |
| id | doaj-art-02cf28a50b9f4976aeae88f4e9e34571 |
| institution | OA Journals |
| issn | 2950-3299 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Molecular Therapy: Oncology |
| spelling | doaj-art-02cf28a50b9f4976aeae88f4e9e345712025-08-20T02:22:16ZengElsevierMolecular Therapy: Oncology2950-32992024-09-0132320085710.1016/j.omton.2024.200857Unveiling promising targets in gastric cancer therapy: A comprehensive reviewWenke Li0Jing Wei1Mo Cheng2Ming Liu3Gastric Cancer Center/Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, ChinaGastric Cancer Center/Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, ChinaGastric Cancer Center/Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, ChinaGastric Cancer Center/Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China; Corresponding author: Ming Liu, Gastric Cancer Center/Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China.Gastric cancer (GC) poses a significant global health challenge, ranking fifth in incidence and third in mortality among all malignancies worldwide. Its insidious onset, aggressive growth, proclivity for metastasis, and limited treatment options have contributed to its high fatality rate. Traditional approaches for GC treatment primarily involve surgery and chemotherapy. However, there is growing interest in targeted therapies and immunotherapies. This comprehensive review highlights recent advancements in GC targeted therapy and immunotherapy. It delves into the mechanisms of various strategies, underscoring their potential in GC treatment. Additionally, the review evaluates the efficacy and safety of relevant clinical trials. Despite the benefits observed in numerous advanced GC patients with targeted therapies and immunotherapies, challenges persist. We discuss pertinent strategies to overcome these challenges, thereby providing a solid foundation for enhancing the clinical effectiveness of targeted therapies and immunotherapies.http://www.sciencedirect.com/science/article/pii/S2950329924000997MT: Regular Issuegastric cancertargeted therapyimmunotherapyclinical trials |
| spellingShingle | Wenke Li Jing Wei Mo Cheng Ming Liu Unveiling promising targets in gastric cancer therapy: A comprehensive review Molecular Therapy: Oncology MT: Regular Issue gastric cancer targeted therapy immunotherapy clinical trials |
| title | Unveiling promising targets in gastric cancer therapy: A comprehensive review |
| title_full | Unveiling promising targets in gastric cancer therapy: A comprehensive review |
| title_fullStr | Unveiling promising targets in gastric cancer therapy: A comprehensive review |
| title_full_unstemmed | Unveiling promising targets in gastric cancer therapy: A comprehensive review |
| title_short | Unveiling promising targets in gastric cancer therapy: A comprehensive review |
| title_sort | unveiling promising targets in gastric cancer therapy a comprehensive review |
| topic | MT: Regular Issue gastric cancer targeted therapy immunotherapy clinical trials |
| url | http://www.sciencedirect.com/science/article/pii/S2950329924000997 |
| work_keys_str_mv | AT wenkeli unveilingpromisingtargetsingastriccancertherapyacomprehensivereview AT jingwei unveilingpromisingtargetsingastriccancertherapyacomprehensivereview AT mocheng unveilingpromisingtargetsingastriccancertherapyacomprehensivereview AT mingliu unveilingpromisingtargetsingastriccancertherapyacomprehensivereview |