Simultaneous Determination of Four Aldehydes in Gas Phase of Mainstream Smoke by Headspace Gas Chromatography-Mass Spectrometry
A method for simultaneous determination of acetaldehyde, propionaldehyde, acrolein, and crotonaldehyde in gas phase of cigarette mainstream smoke by headspace gas chromatography-mass spectrometry was developed and validated. Gas phase components of mainstream cigarette smoke were extracted with meth...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | International Journal of Analytical Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2019/2105839 |
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| author | Xiaotao Zhang Ruoning Wang Li Zhang Jianke Wei Yibin Ruan Weiwei Wang Houwei Ji Jian Liu |
| author_facet | Xiaotao Zhang Ruoning Wang Li Zhang Jianke Wei Yibin Ruan Weiwei Wang Houwei Ji Jian Liu |
| author_sort | Xiaotao Zhang |
| collection | DOAJ |
| description | A method for simultaneous determination of acetaldehyde, propionaldehyde, acrolein, and crotonaldehyde in gas phase of cigarette mainstream smoke by headspace gas chromatography-mass spectrometry was developed and validated. Gas phase components of mainstream cigarette smoke were extracted with methanol, and then the samples were separated on a DB 624 (60 m, 0.32 mm x 1.8 mm) column, analyzed with headspace gas chromatography-mass spectrometry, and quantified by isotope internal standard. The linearities of acetaldehyde, propionaldehyde, acrolein, and crotonaldehyde were good (R2>0.992). The recoveries of acetaldehyde, propionaldehyde, acrolein, and crotonaldehyde were between 78.5% and 115%. The relative standard deviations were less than 10%. The limits of detection and limits of quantitation were 0.014 μg/cigarette ~0.12 μg/cigarette and 0.045 μg/cigarette ~0.38 μg/cigarette, respectively. The method had advantage of high sensitivity, it did not require derivatization of 2,4-dinitrophenylhydrazine and avoided a large number of adverse reactions during the process of derivation to improve the accuracy of result, and it was suitable for quantitative analysis of four aldehydes in gas phase of cigarette mainstream smoke. |
| format | Article |
| id | doaj-art-02bf71171b5c409bb5d6c636d67cf535 |
| institution | Kabale University |
| issn | 1687-8760 1687-8779 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Analytical Chemistry |
| spelling | doaj-art-02bf71171b5c409bb5d6c636d67cf5352025-08-20T03:55:32ZengWileyInternational Journal of Analytical Chemistry1687-87601687-87792019-01-01201910.1155/2019/21058392105839Simultaneous Determination of Four Aldehydes in Gas Phase of Mainstream Smoke by Headspace Gas Chromatography-Mass SpectrometryXiaotao Zhang0Ruoning Wang1Li Zhang2Jianke Wei3Yibin Ruan4Weiwei Wang5Houwei Ji6Jian Liu7Technology Center, China Tobacco Guizhou Industrial Co., Ltd., Guiyang 550009, ChinaMinimal Invasive Center, Tumor Hospital, Sun Yat-Sen University, Guangzhou 510060, ChinaTechnology Center, China Tobacco Guizhou Industrial Co., Ltd., Guiyang 550009, ChinaTechnology Center, China Tobacco Guizhou Industrial Co., Ltd., Guiyang 550009, ChinaTechnology Center, China Tobacco Guizhou Industrial Co., Ltd., Guiyang 550009, ChinaTechnology Center, China Tobacco Guizhou Industrial Co., Ltd., Guiyang 550009, ChinaTechnology Center, China Tobacco Guizhou Industrial Co., Ltd., Guiyang 550009, ChinaTechnology Center, China Tobacco Guizhou Industrial Co., Ltd., Guiyang 550009, ChinaA method for simultaneous determination of acetaldehyde, propionaldehyde, acrolein, and crotonaldehyde in gas phase of cigarette mainstream smoke by headspace gas chromatography-mass spectrometry was developed and validated. Gas phase components of mainstream cigarette smoke were extracted with methanol, and then the samples were separated on a DB 624 (60 m, 0.32 mm x 1.8 mm) column, analyzed with headspace gas chromatography-mass spectrometry, and quantified by isotope internal standard. The linearities of acetaldehyde, propionaldehyde, acrolein, and crotonaldehyde were good (R2>0.992). The recoveries of acetaldehyde, propionaldehyde, acrolein, and crotonaldehyde were between 78.5% and 115%. The relative standard deviations were less than 10%. The limits of detection and limits of quantitation were 0.014 μg/cigarette ~0.12 μg/cigarette and 0.045 μg/cigarette ~0.38 μg/cigarette, respectively. The method had advantage of high sensitivity, it did not require derivatization of 2,4-dinitrophenylhydrazine and avoided a large number of adverse reactions during the process of derivation to improve the accuracy of result, and it was suitable for quantitative analysis of four aldehydes in gas phase of cigarette mainstream smoke.http://dx.doi.org/10.1155/2019/2105839 |
| spellingShingle | Xiaotao Zhang Ruoning Wang Li Zhang Jianke Wei Yibin Ruan Weiwei Wang Houwei Ji Jian Liu Simultaneous Determination of Four Aldehydes in Gas Phase of Mainstream Smoke by Headspace Gas Chromatography-Mass Spectrometry International Journal of Analytical Chemistry |
| title | Simultaneous Determination of Four Aldehydes in Gas Phase of Mainstream Smoke by Headspace Gas Chromatography-Mass Spectrometry |
| title_full | Simultaneous Determination of Four Aldehydes in Gas Phase of Mainstream Smoke by Headspace Gas Chromatography-Mass Spectrometry |
| title_fullStr | Simultaneous Determination of Four Aldehydes in Gas Phase of Mainstream Smoke by Headspace Gas Chromatography-Mass Spectrometry |
| title_full_unstemmed | Simultaneous Determination of Four Aldehydes in Gas Phase of Mainstream Smoke by Headspace Gas Chromatography-Mass Spectrometry |
| title_short | Simultaneous Determination of Four Aldehydes in Gas Phase of Mainstream Smoke by Headspace Gas Chromatography-Mass Spectrometry |
| title_sort | simultaneous determination of four aldehydes in gas phase of mainstream smoke by headspace gas chromatography mass spectrometry |
| url | http://dx.doi.org/10.1155/2019/2105839 |
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