Bidirectional association between depression and cognition in Chinese middle-aged and older women: a 10-year longitudinal study
BackgroundWomen’s health is an important issue worldwide, and as the population is aging, the health of middle-aged and older women is becoming increasingly vital. Although many studies have examined the relationship between cognition and depression, few studies have been conducted specifically with...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1531202/full |
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| author | Xiaoxu Jiang Zheng Jiang Zheng Jiang |
| author_facet | Xiaoxu Jiang Zheng Jiang Zheng Jiang |
| author_sort | Xiaoxu Jiang |
| collection | DOAJ |
| description | BackgroundWomen’s health is an important issue worldwide, and as the population is aging, the health of middle-aged and older women is becoming increasingly vital. Although many studies have examined the relationship between cognition and depression, few studies have been conducted specifically with middle-aged and older women. This study used a longitudinal approach to examine the bidirectional relationship between cognition and depression in middle-aged and older women.MethodsThe study used three waves (2011, 2015, and 2020) of data from the China Health and Retirement Longitudinal Study (CHARLS), enrolling a total of 4,618 middle-aged and older women aged over 45 years. Participants’ general demographic characteristics were analyzed descriptively, and changes in study variables were measured using repeated-measures analysis of variance. Generalized estimating equation (GEE) and cross-lagged models were used to investigate the longitudinal relationship between depression and cognition.ResultsThe results of the GEE and cross-lagged models revealed that previous cognitive problems lead to future depression and prior depressive conditions affect subsequent cognition.ConclusionsThere is a bidirectional relationship between depression and cognition in middle-aged and older women over time. More clinical mechanisms need to be explored in the future. |
| format | Article |
| id | doaj-art-02b9dfac87a14c5b828fc7fb7c406205 |
| institution | DOAJ |
| issn | 1664-0640 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj-art-02b9dfac87a14c5b828fc7fb7c4062052025-08-20T02:55:16ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402025-05-011610.3389/fpsyt.2025.15312021531202Bidirectional association between depression and cognition in Chinese middle-aged and older women: a 10-year longitudinal studyXiaoxu Jiang0Zheng Jiang1Zheng Jiang2Maternal and Child Health Development Research Center, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, ChinaDepartment of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, ChinaShandong Key Laboratory of Brain Health and Function Remodeling, Jinan, ChinaBackgroundWomen’s health is an important issue worldwide, and as the population is aging, the health of middle-aged and older women is becoming increasingly vital. Although many studies have examined the relationship between cognition and depression, few studies have been conducted specifically with middle-aged and older women. This study used a longitudinal approach to examine the bidirectional relationship between cognition and depression in middle-aged and older women.MethodsThe study used three waves (2011, 2015, and 2020) of data from the China Health and Retirement Longitudinal Study (CHARLS), enrolling a total of 4,618 middle-aged and older women aged over 45 years. Participants’ general demographic characteristics were analyzed descriptively, and changes in study variables were measured using repeated-measures analysis of variance. Generalized estimating equation (GEE) and cross-lagged models were used to investigate the longitudinal relationship between depression and cognition.ResultsThe results of the GEE and cross-lagged models revealed that previous cognitive problems lead to future depression and prior depressive conditions affect subsequent cognition.ConclusionsThere is a bidirectional relationship between depression and cognition in middle-aged and older women over time. More clinical mechanisms need to be explored in the future.https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1531202/fulldepressioncognitionChinese middle-aged and older femalesCHARLSlongitudinal |
| spellingShingle | Xiaoxu Jiang Zheng Jiang Zheng Jiang Bidirectional association between depression and cognition in Chinese middle-aged and older women: a 10-year longitudinal study Frontiers in Psychiatry depression cognition Chinese middle-aged and older females CHARLS longitudinal |
| title | Bidirectional association between depression and cognition in Chinese middle-aged and older women: a 10-year longitudinal study |
| title_full | Bidirectional association between depression and cognition in Chinese middle-aged and older women: a 10-year longitudinal study |
| title_fullStr | Bidirectional association between depression and cognition in Chinese middle-aged and older women: a 10-year longitudinal study |
| title_full_unstemmed | Bidirectional association between depression and cognition in Chinese middle-aged and older women: a 10-year longitudinal study |
| title_short | Bidirectional association between depression and cognition in Chinese middle-aged and older women: a 10-year longitudinal study |
| title_sort | bidirectional association between depression and cognition in chinese middle aged and older women a 10 year longitudinal study |
| topic | depression cognition Chinese middle-aged and older females CHARLS longitudinal |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1531202/full |
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