Inhibition of SARS–CoV–2 NSP–15 by Uridine–5′–Monophosphate Analogues Using QSAR Modelling, Molecular Dynamics Simulations, and Free Energy Landscape
SARS–CoV–2 is accountable for severe social and economic disruption around the world causing COVID–19. Non–structural protein–15 (NSP15) possesses a domain that is vital to the viral life cycle and is known as uridylate–specific endoribonuclease (EndoU). This domain binds to the uridine 5′–monophosp...
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| Main Author: | |
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| Format: | Article |
| Language: | English |
| Published: |
Springer
2024-01-01
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| Series: | Saudi Pharmaceutical Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319016423004097 |
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