The role of dendritic cells in tertiary lymphoid structures: implications in cancer and autoimmune diseases
Tertiary Lymphoid Structures (TLS) are organized aggregates of immune cells such as T cells, B cells, and Dendritic Cells (DCs), as well as fibroblasts, formed postnatally in response to signals from cytokines and chemokines. Central to the function of TLS are DCs, professional antigen-presenting ce...
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Frontiers Media S.A.
2024-10-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1439413/full |
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| author | Mariana Reste Kristi Ajazi Ayca Sayi-Yazgan Ayca Sayi-Yazgan Radmila Jankovic Biljana Bufan Sven Brandau Espen S. Bækkevold Florent Petitprez Malin Lindstedt Gosse J. Adema Catarina R. Almeida |
| author_facet | Mariana Reste Kristi Ajazi Ayca Sayi-Yazgan Ayca Sayi-Yazgan Radmila Jankovic Biljana Bufan Sven Brandau Espen S. Bækkevold Florent Petitprez Malin Lindstedt Gosse J. Adema Catarina R. Almeida |
| author_sort | Mariana Reste |
| collection | DOAJ |
| description | Tertiary Lymphoid Structures (TLS) are organized aggregates of immune cells such as T cells, B cells, and Dendritic Cells (DCs), as well as fibroblasts, formed postnatally in response to signals from cytokines and chemokines. Central to the function of TLS are DCs, professional antigen-presenting cells (APCs) that coordinate the adaptive immune response, and which can be classified into different subsets, with specific functions, and markers. In this article, we review current data on the contribution of different DC subsets to TLS function in cancer and autoimmunity, two opposite sides of the immune response. Different DC subsets can be found in different tumor types, correlating with cancer prognosis. Moreover, DCs are also present in TLS found in autoimmune and inflammatory conditions, contributing to disease development. Broadly, the presence of DCs in TLS appears to be associated with favorable clinical outcomes in cancer while in autoimmune pathologies these cells are associated with unfavorable prognosis. Therefore, it is important to analyze the complex functions of DCs within TLS in order to enhance our fundamental understanding of immune regulation but also as a possible route to create innovative clinical interventions designed for the specific needs of patients with diverse pathological diseases. |
| format | Article |
| id | doaj-art-02a9a8a5f7224814a31a9a5c36c57470 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-02a9a8a5f7224814a31a9a5c36c574702025-02-07T09:33:12ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-10-011510.3389/fimmu.2024.14394131439413The role of dendritic cells in tertiary lymphoid structures: implications in cancer and autoimmune diseasesMariana Reste0Kristi Ajazi1Ayca Sayi-Yazgan2Ayca Sayi-Yazgan3Radmila Jankovic4Biljana Bufan5Sven Brandau6Espen S. Bækkevold7Florent Petitprez8Malin Lindstedt9Gosse J. Adema10Catarina R. Almeida11Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro, PortugalDepartment of Immunotechnology, Lund University, Lund, SwedenDepartment of Molecular Biology and Genetics, Faculty of Science and Letters, Istanbul Technical University, Istanbul, TürkiyeDepartment of Life Sciences, Centre for Inflammation Research and Translational Medicine, College of Health and Life Sciences, Brunel University London, Uxbridge, United KingdomFaculty of Medicine, Institute of Pathology, University of Belgrade, Belgrade, SerbiaDepartment of Microbiology and Immunology, University of Belgrade - Faculty of Pharmacy, Belgrade, SerbiaExperimental and Translational Research, Department of Otorhinolaryngology, University Hospital Essen, Essen, GermanyDepartment of Pathology, Oslo University Hospital-Rikshospitalet, Oslo, NorwayCentre for Reproductive Health, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, United KingdomDepartment of Immunotechnology, Lund University, Lund, Sweden0Radiotherapy & OncoImmunology Laboratory, Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, NetherlandsInstitute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro, PortugalTertiary Lymphoid Structures (TLS) are organized aggregates of immune cells such as T cells, B cells, and Dendritic Cells (DCs), as well as fibroblasts, formed postnatally in response to signals from cytokines and chemokines. Central to the function of TLS are DCs, professional antigen-presenting cells (APCs) that coordinate the adaptive immune response, and which can be classified into different subsets, with specific functions, and markers. In this article, we review current data on the contribution of different DC subsets to TLS function in cancer and autoimmunity, two opposite sides of the immune response. Different DC subsets can be found in different tumor types, correlating with cancer prognosis. Moreover, DCs are also present in TLS found in autoimmune and inflammatory conditions, contributing to disease development. Broadly, the presence of DCs in TLS appears to be associated with favorable clinical outcomes in cancer while in autoimmune pathologies these cells are associated with unfavorable prognosis. Therefore, it is important to analyze the complex functions of DCs within TLS in order to enhance our fundamental understanding of immune regulation but also as a possible route to create innovative clinical interventions designed for the specific needs of patients with diverse pathological diseases.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1439413/fulltertiary lymphoid structures (TLS)tertiary lymphoid organs (TLO)dendritic cells (DC)anti-tumor immunityautoimmunity |
| spellingShingle | Mariana Reste Kristi Ajazi Ayca Sayi-Yazgan Ayca Sayi-Yazgan Radmila Jankovic Biljana Bufan Sven Brandau Espen S. Bækkevold Florent Petitprez Malin Lindstedt Gosse J. Adema Catarina R. Almeida The role of dendritic cells in tertiary lymphoid structures: implications in cancer and autoimmune diseases Frontiers in Immunology tertiary lymphoid structures (TLS) tertiary lymphoid organs (TLO) dendritic cells (DC) anti-tumor immunity autoimmunity |
| title | The role of dendritic cells in tertiary lymphoid structures: implications in cancer and autoimmune diseases |
| title_full | The role of dendritic cells in tertiary lymphoid structures: implications in cancer and autoimmune diseases |
| title_fullStr | The role of dendritic cells in tertiary lymphoid structures: implications in cancer and autoimmune diseases |
| title_full_unstemmed | The role of dendritic cells in tertiary lymphoid structures: implications in cancer and autoimmune diseases |
| title_short | The role of dendritic cells in tertiary lymphoid structures: implications in cancer and autoimmune diseases |
| title_sort | role of dendritic cells in tertiary lymphoid structures implications in cancer and autoimmune diseases |
| topic | tertiary lymphoid structures (TLS) tertiary lymphoid organs (TLO) dendritic cells (DC) anti-tumor immunity autoimmunity |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1439413/full |
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