Balloon Cell Urethral Melanoma: Differential Diagnosis and Management
Introduction. Primary malignant melanoma of the urethra is a rare tumour (0.2% of all melanomas) that most commonly affects the meatus and distal urethra and is three times more common in women than men. Case. A 76-year-old lady presented with vaginal pain and discharge. On examination, a 4 cm mass...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Obstetrics and Gynecology |
| Online Access: | http://dx.doi.org/10.1155/2015/919584 |
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| author | M. McComiskey C. Iavazzo M. Datta R. Slade B. Winter-Roach G. Lambe V. K. Sangar M. Smith |
| author_facet | M. McComiskey C. Iavazzo M. Datta R. Slade B. Winter-Roach G. Lambe V. K. Sangar M. Smith |
| author_sort | M. McComiskey |
| collection | DOAJ |
| description | Introduction. Primary malignant melanoma of the urethra is a rare tumour (0.2% of all melanomas) that most commonly affects the meatus and distal urethra and is three times more common in women than men. Case. A 76-year-old lady presented with vaginal pain and discharge. On examination, a 4 cm mass was noted in the vagina and biopsy confirmed melanoma of a balloon type. Preoperative CT showed no distant metastases and an MRI scan of the pelvis demonstrated no associated lymphadenopathy. She underwent anterior exenterative surgery and vaginectomy also. Histology confirmed a urethral nodular malignant melanoma. Discussion. First-line treatment of melanoma is often surgical. Adjuvant treatment including chemotherapy, radiotherapy, or immunotherapy has also been reported. Even with aggressive management, malignant melanoma of the urogenital tract generally has a poor prognosis. Recurrence rates are high and the mean period between diagnosis and recurrence is 12.5 months. A 5-year survival rate of less than 20% has been reported in balloon cell melanomas along with nearly 20% developing local recurrence. Conclusion. To the best of our knowledge, this case is the first report of balloon cell melanoma arising in the urethra. The presentation and surgical management has been described and a literature review provided. |
| format | Article |
| id | doaj-art-02a22bc400ca4f3ebdaf7e90e5efe876 |
| institution | Kabale University |
| issn | 2090-6684 2090-6692 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Obstetrics and Gynecology |
| spelling | doaj-art-02a22bc400ca4f3ebdaf7e90e5efe8762025-02-03T01:00:09ZengWileyCase Reports in Obstetrics and Gynecology2090-66842090-66922015-01-01201510.1155/2015/919584919584Balloon Cell Urethral Melanoma: Differential Diagnosis and ManagementM. McComiskey0C. Iavazzo1M. Datta2R. Slade3B. Winter-Roach4G. Lambe5V. K. Sangar6M. Smith7Gynaecological Oncology Department, Christie Hospital, Manchester M20 4BX, UKGynaecological Oncology Department, Christie Hospital, Manchester M20 4BX, UKGynaecological Oncology Department, Christie Hospital, Manchester M20 4BX, UKGynaecological Oncology Department, Christie Hospital, Manchester M20 4BX, UKGynaecological Oncology Department, Christie Hospital, Manchester M20 4BX, UKPlastic Surgery Department, Christie Hospital, Manchester M20 4BX, UKUrology Department, Christie Hospital, Manchester M20 4BX, UKGynaecological Oncology Department, Christie Hospital, Manchester M20 4BX, UKIntroduction. Primary malignant melanoma of the urethra is a rare tumour (0.2% of all melanomas) that most commonly affects the meatus and distal urethra and is three times more common in women than men. Case. A 76-year-old lady presented with vaginal pain and discharge. On examination, a 4 cm mass was noted in the vagina and biopsy confirmed melanoma of a balloon type. Preoperative CT showed no distant metastases and an MRI scan of the pelvis demonstrated no associated lymphadenopathy. She underwent anterior exenterative surgery and vaginectomy also. Histology confirmed a urethral nodular malignant melanoma. Discussion. First-line treatment of melanoma is often surgical. Adjuvant treatment including chemotherapy, radiotherapy, or immunotherapy has also been reported. Even with aggressive management, malignant melanoma of the urogenital tract generally has a poor prognosis. Recurrence rates are high and the mean period between diagnosis and recurrence is 12.5 months. A 5-year survival rate of less than 20% has been reported in balloon cell melanomas along with nearly 20% developing local recurrence. Conclusion. To the best of our knowledge, this case is the first report of balloon cell melanoma arising in the urethra. The presentation and surgical management has been described and a literature review provided.http://dx.doi.org/10.1155/2015/919584 |
| spellingShingle | M. McComiskey C. Iavazzo M. Datta R. Slade B. Winter-Roach G. Lambe V. K. Sangar M. Smith Balloon Cell Urethral Melanoma: Differential Diagnosis and Management Case Reports in Obstetrics and Gynecology |
| title | Balloon Cell Urethral Melanoma: Differential Diagnosis and Management |
| title_full | Balloon Cell Urethral Melanoma: Differential Diagnosis and Management |
| title_fullStr | Balloon Cell Urethral Melanoma: Differential Diagnosis and Management |
| title_full_unstemmed | Balloon Cell Urethral Melanoma: Differential Diagnosis and Management |
| title_short | Balloon Cell Urethral Melanoma: Differential Diagnosis and Management |
| title_sort | balloon cell urethral melanoma differential diagnosis and management |
| url | http://dx.doi.org/10.1155/2015/919584 |
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