Regular exercise in adolescents with ACE gene polymorphism helps preventing cardiovascular risk factors
Introduction: Polymorphisms can influence the expression and production of regulatory components in the endocrine system. These include the renin-angiotensin-aldosterone system (RAAS), which plays, along with other environmental factors, a fundamental role in the pathogenesis of essential arterial...
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Faculdade de Medicina do ABC
2025-02-01
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| Series: | ABCS Health Sciences |
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| Online Access: | https://nepas.emnuvens.com.br/abcshs/article/view/2746 |
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| author | Nivaldo de Jesus Silva Soares Junior Carlan Senna Carlos Alberto Alves Dias-Filho Bruno Rodrigues Maria Claudia Irigoyen Danielle da Silva Dias Vinícius Santos Mendes Carlos José Moraes Dias Sally Cristina Moutinho Monteiro Cristiano Teixeira Mostarda |
| author_facet | Nivaldo de Jesus Silva Soares Junior Carlan Senna Carlos Alberto Alves Dias-Filho Bruno Rodrigues Maria Claudia Irigoyen Danielle da Silva Dias Vinícius Santos Mendes Carlos José Moraes Dias Sally Cristina Moutinho Monteiro Cristiano Teixeira Mostarda |
| author_sort | Nivaldo de Jesus Silva Soares Junior |
| collection | DOAJ |
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Introduction: Polymorphisms can influence the expression and production of regulatory components in the endocrine system. These include the renin-angiotensin-aldosterone system (RAAS), which plays, along with other environmental factors, a fundamental role in the pathogenesis of essential arterial hypertension in both adults and adolescents. Objective: To analyze the influence of the level of physical activity and the polymorphism in the ACE gene on cardiac autonomic modulation and the chance of cardiovascular risk in adolescents. Methods: 136 adolescents were divided into active (AG) and sedentary (SG) groups. The genotypic frequencies in SG group are DD (38), DI (12) and II (10); and AG group are DD (38), DI (15) and II (23). Blood pressure, body composition, physical activity level, and sexual maturation were assessed to characterize the groups. Afterward, an electrocardiogram was performed to analyze heart rate variability and oral mucosal cells were collected for the genotypic of angiotensin-converting enzyme. Results: The AG presented lower systolic blood pressure and sympathetic modulation when compared to the SG DD. Additionally, the odds ratio for the cardiovascular events was increased in the SG DD compared with that in AG with DD allele (AG DD) adolescents, as verified for the autonomic variables LF%, HF%, LF/HF, and SBP. Conclusion: Regular physical activity in adolescents can contribute to the maintenance of blood pressure levels, preventing autonomic imbalance and cardiovascular risk factors in adolescents with ACE gene polymorphism.
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| format | Article |
| id | doaj-art-029ba9e1d69040eda4460813815f6473 |
| institution | Kabale University |
| issn | 2318-4965 2357-8114 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Faculdade de Medicina do ABC |
| record_format | Article |
| series | ABCS Health Sciences |
| spelling | doaj-art-029ba9e1d69040eda4460813815f64732025-02-10T05:41:10ZengFaculdade de Medicina do ABCABCS Health Sciences2318-49652357-81142025-02-0110.7322/abcshs.2023168.2746Regular exercise in adolescents with ACE gene polymorphism helps preventing cardiovascular risk factorsNivaldo de Jesus Silva Soares Junior0Carlan Senna1Carlos Alberto Alves Dias-Filho2Bruno Rodrigues3Maria Claudia Irigoyen4Danielle da Silva Dias5Vinícius Santos Mendes6Carlos José Moraes Dias7Sally Cristina Moutinho Monteiro8Cristiano Teixeira Mostarda9Programa de Pós-Graduação em Educação Física, Universidade Federal do Maranhão (UFMA) – São Luís (MA), BrazilDepartamento de Educação Física, Laboratório de Adaptação Cardiovascular ao Exercício UFMA – São Luís (MA), BrazilDepartamento de Educação Física, Laboratório de Adaptação Cardiovascular ao Exercício UFMA – São Luís (MA), BrazilLaboratório de Investigação Cardiovascular e Exercício (LICE), Faculdade de Educação Física, Universidade Estadual de Campinas (UNICAMP) – Campinas (SP), BrazilDepartamento de Cardiopneumologia, Faculdade de Medicina, Universidade de São Paulo (USP) – São Paulo (SP), BrazilPrograma de Pós-Graduação em Educação Física, Universidade Federal do Maranhão (UFMA) – São Luís (MA), BrazilCurso de Medicina, UFMA – São Luís (MA), BrazilPrograma de Pós-Graduação em Educação Física, Universidade Federal do Maranhão (UFMA) – São Luís (MA), Brazil / Departamento de Educação Física, Laboratório de Adaptação Cardiovascular ao Exercício UFMA – São Luís (MA), BrazilDepartamento de Educação Física, Laboratório de Adaptação Cardiovascular ao Exercício UFMA – São Luís (MA), BrazilPrograma de Pós-Graduação em Educação Física, Universidade Federal do Maranhão (UFMA) - São Luís (MA), Brazil /Departamento de Educação Física, Laboratório de Adaptação Cardiovascular ao Exercício UFMA - São Luís (MA), Brazil Introduction: Polymorphisms can influence the expression and production of regulatory components in the endocrine system. These include the renin-angiotensin-aldosterone system (RAAS), which plays, along with other environmental factors, a fundamental role in the pathogenesis of essential arterial hypertension in both adults and adolescents. Objective: To analyze the influence of the level of physical activity and the polymorphism in the ACE gene on cardiac autonomic modulation and the chance of cardiovascular risk in adolescents. Methods: 136 adolescents were divided into active (AG) and sedentary (SG) groups. The genotypic frequencies in SG group are DD (38), DI (12) and II (10); and AG group are DD (38), DI (15) and II (23). Blood pressure, body composition, physical activity level, and sexual maturation were assessed to characterize the groups. Afterward, an electrocardiogram was performed to analyze heart rate variability and oral mucosal cells were collected for the genotypic of angiotensin-converting enzyme. Results: The AG presented lower systolic blood pressure and sympathetic modulation when compared to the SG DD. Additionally, the odds ratio for the cardiovascular events was increased in the SG DD compared with that in AG with DD allele (AG DD) adolescents, as verified for the autonomic variables LF%, HF%, LF/HF, and SBP. Conclusion: Regular physical activity in adolescents can contribute to the maintenance of blood pressure levels, preventing autonomic imbalance and cardiovascular risk factors in adolescents with ACE gene polymorphism. https://nepas.emnuvens.com.br/abcshs/article/view/2746adolescentAngiotensin-converting enzyme inhibitorsexerciseAutonomic nervous systemcardiovascular system |
| spellingShingle | Nivaldo de Jesus Silva Soares Junior Carlan Senna Carlos Alberto Alves Dias-Filho Bruno Rodrigues Maria Claudia Irigoyen Danielle da Silva Dias Vinícius Santos Mendes Carlos José Moraes Dias Sally Cristina Moutinho Monteiro Cristiano Teixeira Mostarda Regular exercise in adolescents with ACE gene polymorphism helps preventing cardiovascular risk factors ABCS Health Sciences adolescent Angiotensin-converting enzyme inhibitors exercise Autonomic nervous system cardiovascular system |
| title | Regular exercise in adolescents with ACE gene polymorphism helps preventing cardiovascular risk factors |
| title_full | Regular exercise in adolescents with ACE gene polymorphism helps preventing cardiovascular risk factors |
| title_fullStr | Regular exercise in adolescents with ACE gene polymorphism helps preventing cardiovascular risk factors |
| title_full_unstemmed | Regular exercise in adolescents with ACE gene polymorphism helps preventing cardiovascular risk factors |
| title_short | Regular exercise in adolescents with ACE gene polymorphism helps preventing cardiovascular risk factors |
| title_sort | regular exercise in adolescents with ace gene polymorphism helps preventing cardiovascular risk factors |
| topic | adolescent Angiotensin-converting enzyme inhibitors exercise Autonomic nervous system cardiovascular system |
| url | https://nepas.emnuvens.com.br/abcshs/article/view/2746 |
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