Effects of Sildenafil and Vitamin E on Paraquat-Induced Pulmonary Fibrosis in Rats

Paraquat, specifically concentrated in lung tissue, leads to lung damage through oxidative and inflammatory processes. Pulmonary fibrosis occurs due to inflammation and an imbalance in the antioxidant system. Drugs like sildenafil, which inhibits phosphodiesterase enzymes, are used to treat pulmonar...

Full description

Saved in:
Bibliographic Details
Main Authors: Fouziyeh Siahpour, Hosein Sadeghi, Esmaeel Panahi kokhdan, Mohammad Khoshnoud
Format: Article
Language:English
Published: Shiraz University of Medical Sciences 2024-12-01
Series:Trends in Pharmaceutical Sciences
Subjects:
Online Access:https://tips.sums.ac.ir/article_50536_617ff9bd34fc087abfdefb2135e03804.pdf
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1823864051832193024
author Fouziyeh Siahpour
Hosein Sadeghi
Esmaeel Panahi kokhdan
Mohammad Khoshnoud
author_facet Fouziyeh Siahpour
Hosein Sadeghi
Esmaeel Panahi kokhdan
Mohammad Khoshnoud
author_sort Fouziyeh Siahpour
collection DOAJ
description Paraquat, specifically concentrated in lung tissue, leads to lung damage through oxidative and inflammatory processes. Pulmonary fibrosis occurs due to inflammation and an imbalance in the antioxidant system. Drugs like sildenafil, which inhibits phosphodiesterase enzymes, are used to treat pulmonary arterial hypertension. Antioxidants such as vitamin E can restore the oxidant-antioxidant balance. This study aimed to evaluate the effects of sildenafil and vitamin E on paraquat-induced pulmonary fibrosis. Male Wistar rats were used in animal studies. Paraquat was administered orally (R1-1) at a single dose of 40 mg/kg to induce lung fibrosis. Three groups were studied: Sildenafil administered orally (10 mg/kg) for 14 days. Vitamin E administered orally (500 mg/kg) for 14 days. Simultaneous administration of vitamin E (500 mg/kg) and sildenafil (10 mg/kg) for 14 days. Biochemical and histopathological tests were performed and compared with a control group. Paraquat administration caused fibrosis and an oxidant-antioxidant imbalance in lung tissue. Treatment with sildenafil and vitamin E increased glutathione (total GSH) and superoxide dismutase (SOD) levels while decreasing malondialdehyde (MDA) and hydroxyproline (HYP) levels compared to the paraquat group. Tumor Necrosis Factor-α (TNF-α) showed no significant changes in the study group compared to the control group. Treatment with sildenafil and vitamin E improved the oxidant-antioxidant balance in lung tissue exposed to paraquat. Additionally, this study demonstrated significant antioxidant effects of sildenafil and vitamin E against paraquat-induced oxidative damage.
format Article
id doaj-art-029a13fa125f41baafb19368b4d69790
institution Kabale University
issn 2423-5652
language English
publishDate 2024-12-01
publisher Shiraz University of Medical Sciences
record_format Article
series Trends in Pharmaceutical Sciences
spelling doaj-art-029a13fa125f41baafb19368b4d697902025-02-09T08:20:03ZengShiraz University of Medical SciencesTrends in Pharmaceutical Sciences2423-56522024-12-0110432333210.30476/tips.2024.103997.125550536Effects of Sildenafil and Vitamin E on Paraquat-Induced Pulmonary Fibrosis in RatsFouziyeh Siahpour0Hosein Sadeghi1Esmaeel Panahi kokhdan2Mohammad Khoshnoud3Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran.Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran.Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.Paraquat, specifically concentrated in lung tissue, leads to lung damage through oxidative and inflammatory processes. Pulmonary fibrosis occurs due to inflammation and an imbalance in the antioxidant system. Drugs like sildenafil, which inhibits phosphodiesterase enzymes, are used to treat pulmonary arterial hypertension. Antioxidants such as vitamin E can restore the oxidant-antioxidant balance. This study aimed to evaluate the effects of sildenafil and vitamin E on paraquat-induced pulmonary fibrosis. Male Wistar rats were used in animal studies. Paraquat was administered orally (R1-1) at a single dose of 40 mg/kg to induce lung fibrosis. Three groups were studied: Sildenafil administered orally (10 mg/kg) for 14 days. Vitamin E administered orally (500 mg/kg) for 14 days. Simultaneous administration of vitamin E (500 mg/kg) and sildenafil (10 mg/kg) for 14 days. Biochemical and histopathological tests were performed and compared with a control group. Paraquat administration caused fibrosis and an oxidant-antioxidant imbalance in lung tissue. Treatment with sildenafil and vitamin E increased glutathione (total GSH) and superoxide dismutase (SOD) levels while decreasing malondialdehyde (MDA) and hydroxyproline (HYP) levels compared to the paraquat group. Tumor Necrosis Factor-α (TNF-α) showed no significant changes in the study group compared to the control group. Treatment with sildenafil and vitamin E improved the oxidant-antioxidant balance in lung tissue exposed to paraquat. Additionally, this study demonstrated significant antioxidant effects of sildenafil and vitamin E against paraquat-induced oxidative damage.https://tips.sums.ac.ir/article_50536_617ff9bd34fc087abfdefb2135e03804.pdfparaquatsildenafilvitamin epulmonary fibrosis
spellingShingle Fouziyeh Siahpour
Hosein Sadeghi
Esmaeel Panahi kokhdan
Mohammad Khoshnoud
Effects of Sildenafil and Vitamin E on Paraquat-Induced Pulmonary Fibrosis in Rats
Trends in Pharmaceutical Sciences
paraquat
sildenafil
vitamin e
pulmonary fibrosis
title Effects of Sildenafil and Vitamin E on Paraquat-Induced Pulmonary Fibrosis in Rats
title_full Effects of Sildenafil and Vitamin E on Paraquat-Induced Pulmonary Fibrosis in Rats
title_fullStr Effects of Sildenafil and Vitamin E on Paraquat-Induced Pulmonary Fibrosis in Rats
title_full_unstemmed Effects of Sildenafil and Vitamin E on Paraquat-Induced Pulmonary Fibrosis in Rats
title_short Effects of Sildenafil and Vitamin E on Paraquat-Induced Pulmonary Fibrosis in Rats
title_sort effects of sildenafil and vitamin e on paraquat induced pulmonary fibrosis in rats
topic paraquat
sildenafil
vitamin e
pulmonary fibrosis
url https://tips.sums.ac.ir/article_50536_617ff9bd34fc087abfdefb2135e03804.pdf
work_keys_str_mv AT fouziyehsiahpour effectsofsildenafilandvitamineonparaquatinducedpulmonaryfibrosisinrats
AT hoseinsadeghi effectsofsildenafilandvitamineonparaquatinducedpulmonaryfibrosisinrats
AT esmaeelpanahikokhdan effectsofsildenafilandvitamineonparaquatinducedpulmonaryfibrosisinrats
AT mohammadkhoshnoud effectsofsildenafilandvitamineonparaquatinducedpulmonaryfibrosisinrats