Mechanical compression induces chondrocyte hypertrophy by regulating Runx2 O-GlcNAcylation during temporomandibular joint condyle degeneration

Mechanical compression induces chondrocyte hypertrophy by regulating Runx2 O-GlcNAcylation during temporomandibular joint condyle degeneration

Aims: Excessive chondrocyte hypertrophy is a common feature in cartilage degeneration which is susceptible to joint overloading, but the relationship between mechanical overloading and chondrocyte hypertrophy still remains elusive. The aim of our study was to explore the mechanism of mechanical com...

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Bibliographic Details
Main Authors:	Yan Xiao, Zhang Yue, He Zijing, Zheng Yao, Mao Sui, Zeng Xuemin, Zhang Qiang, Yuan Xiao, Ren Dapeng
Format:	Article
Language:	English
Published:	The British Editorial Society of Bone & Joint Surgery 2025-03-01
Series:	Bone & Joint Research
Subjects:	chondrocyte hypertrophy o-glcnacylation compression tmj temporomandibular joint condyles chondrocytes glucose transporter 1 (glut1) cartilage degeneration staining rat models cartilage tissues aggrecan
Online Access:	https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.143.BJR-2024-0257.R1
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