Capsaicin-induced secondary hyperalgesia differences between the trigeminal and spinal innervation

Capsaicin-induced secondary hyperalgesia differences between the trigeminal and spinal innervation

Abstract This study compared the degree of secondary hyperalgesia and somatosensory threshold changes induced by topical capsaicin between spinal and trigeminal innervation. This crossover clinical trial included 40 healthy individuals in which 0.25 g of 1% capsaicin cream was randomly applied for 4...

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Bibliographic Details
Main Authors: Isabela C. Novaes, Soraya S. Ardestani, Allen Matheus S. Nascimento, Paulo C. R. Conti, Leonardo R. Bonjardim, Peter Svensson, Fernando G. Exposto, Yuri M. Costa
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Capsaicin
Central sensitization
Secondary hyperalgesia
Orofacial pain
Online Access:https://doi.org/10.1038/s41598-024-83312-8
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