Non-alcoholic fatty liver disease and the gut microbiota in adolescents: is there a relationship?
Abstract Background Despite the increasing prevalence of nonalcoholic fatty liver disease (NAFLD), the pathophysiology is still not fully understood. Recent evidence suggests that the gut microbiota may play a role in the pathophysiology of NAFLD and may also offer new therapeutic options. Methods T...
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BMC
2024-11-01
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| Series: | BMC Pediatrics |
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| Online Access: | https://doi.org/10.1186/s12887-024-05268-y |
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| author | Doaa El Amrousy Heba El Ashry Sara Maher Yousef Elsayed Samir Hasan |
| author_facet | Doaa El Amrousy Heba El Ashry Sara Maher Yousef Elsayed Samir Hasan |
| author_sort | Doaa El Amrousy |
| collection | DOAJ |
| description | Abstract Background Despite the increasing prevalence of nonalcoholic fatty liver disease (NAFLD), the pathophysiology is still not fully understood. Recent evidence suggests that the gut microbiota may play a role in the pathophysiology of NAFLD and may also offer new therapeutic options. Methods This prospective cross-sectional study included 100 consecutive newly diagnosed obese patients (BMI ≥ 95th percentile), aged 14–18 years with NAFLD (confirmed by ultrasound), persistently elevated levels of alanine aminotransferase (ALT) greater than 60 U/L for 1–6 months, and 100 healthy controls. We evaluated changes in the gut microbiota in NAFLD adolescents compared with healthy controls. Results According to the multiple logistic regressions, the variables associated with NAFLD were the presence of Clostridium difficile, the presence of Salmonella spp., a greater abundance of Bifidobacterium and Prevotella, and a lower abundance of Lactobacillus. Conclusion Changes in the gut microbiota occur in adolescents with NAFLD compared with healthy individuals, which may be useful for identifying youths who are amenable to gut microbiota-based interventions. Clinical trial number Not applicable. |
| format | Article |
| id | doaj-art-02871c9d986c4ed98f81caedf00a7606 |
| institution | OA Journals |
| issn | 1471-2431 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pediatrics |
| spelling | doaj-art-02871c9d986c4ed98f81caedf00a76062025-08-20T02:38:35ZengBMCBMC Pediatrics1471-24312024-11-0124111010.1186/s12887-024-05268-yNon-alcoholic fatty liver disease and the gut microbiota in adolescents: is there a relationship?Doaa El Amrousy0Heba El Ashry1Sara Maher2Yousef Elsayed3Samir Hasan4Pediatric Department, Faculty of Medicine, Tanta UniversityTropical Medicine Departments, Faculty of Medicine, Tanta UniversityTheodor Bilharz Research InstituteKasr El Ainy Medical School, Cairo UniversityPediatric Department, Faculty of Medicine, Tanta UniversityAbstract Background Despite the increasing prevalence of nonalcoholic fatty liver disease (NAFLD), the pathophysiology is still not fully understood. Recent evidence suggests that the gut microbiota may play a role in the pathophysiology of NAFLD and may also offer new therapeutic options. Methods This prospective cross-sectional study included 100 consecutive newly diagnosed obese patients (BMI ≥ 95th percentile), aged 14–18 years with NAFLD (confirmed by ultrasound), persistently elevated levels of alanine aminotransferase (ALT) greater than 60 U/L for 1–6 months, and 100 healthy controls. We evaluated changes in the gut microbiota in NAFLD adolescents compared with healthy controls. Results According to the multiple logistic regressions, the variables associated with NAFLD were the presence of Clostridium difficile, the presence of Salmonella spp., a greater abundance of Bifidobacterium and Prevotella, and a lower abundance of Lactobacillus. Conclusion Changes in the gut microbiota occur in adolescents with NAFLD compared with healthy individuals, which may be useful for identifying youths who are amenable to gut microbiota-based interventions. Clinical trial number Not applicable.https://doi.org/10.1186/s12887-024-05268-yAdolescentsMetabolic dysfunction–associated steatotic liver diseaseGut microbiota |
| spellingShingle | Doaa El Amrousy Heba El Ashry Sara Maher Yousef Elsayed Samir Hasan Non-alcoholic fatty liver disease and the gut microbiota in adolescents: is there a relationship? BMC Pediatrics Adolescents Metabolic dysfunction–associated steatotic liver disease Gut microbiota |
| title | Non-alcoholic fatty liver disease and the gut microbiota in adolescents: is there a relationship? |
| title_full | Non-alcoholic fatty liver disease and the gut microbiota in adolescents: is there a relationship? |
| title_fullStr | Non-alcoholic fatty liver disease and the gut microbiota in adolescents: is there a relationship? |
| title_full_unstemmed | Non-alcoholic fatty liver disease and the gut microbiota in adolescents: is there a relationship? |
| title_short | Non-alcoholic fatty liver disease and the gut microbiota in adolescents: is there a relationship? |
| title_sort | non alcoholic fatty liver disease and the gut microbiota in adolescents is there a relationship |
| topic | Adolescents Metabolic dysfunction–associated steatotic liver disease Gut microbiota |
| url | https://doi.org/10.1186/s12887-024-05268-y |
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