Double Allogenic Mesenchymal Stem Cells Transplantations Could Not Enhance Therapeutic Effect Compared with Single Transplantation in Systemic Lupus Erythematosus
The clinical trial of allogenic mesenchymal stem cells (MSCs) transplantation for refractory SLE patients has shown significant safety and efficacy profiles. However, the optimum frequency of the MSCs transplantation (MSCT) is unknown. This study was undertaken to observe whether double transplantat...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/273291 |
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| author | Dandan Wang Kentaro Akiyama Huayong Zhang Takayoshi Yamaza Xia Li Xuebing Feng Hong Wang Bingzhu Hua Bujun Liu Huji Xu Wanjun Chen Songtao Shi Lingyun Sun |
| author_facet | Dandan Wang Kentaro Akiyama Huayong Zhang Takayoshi Yamaza Xia Li Xuebing Feng Hong Wang Bingzhu Hua Bujun Liu Huji Xu Wanjun Chen Songtao Shi Lingyun Sun |
| author_sort | Dandan Wang |
| collection | DOAJ |
| description | The clinical trial of allogenic mesenchymal stem cells (MSCs) transplantation for refractory SLE patients has shown significant safety and efficacy profiles. However, the optimum frequency of the MSCs transplantation (MSCT) is unknown. This study was undertaken to observe whether double transplantations of MSCs is superior to single transplantation. Fifty-eight refractory SLE patients were enrolled in this study, in which 30 were randomly given single MSCT, and the other 28 were given double MSCT. Patients were followed up for rates of survival, disease remission, and relapse, as well as transplantation-related adverse events. SLE disease activity index (SLEDAI) and serologic features were evaluated. Our results showed that no remarkable differences between single and double allogenic MSCT were found in terms of disease remission and relapse, amelioration of disease activity, and serum indexes in an SLE clinical trial with more than one year followup. This study demonstrated that single MSCs transplantation at the dose of one million MSCs per kilogram of body weight was sufficient to induce disease remission for refractory SLE patients. |
| format | Article |
| id | doaj-art-02829d264fe7441eb378deb2ecd5e116 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-02829d264fe7441eb378deb2ecd5e1162025-08-20T03:54:15ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/273291273291Double Allogenic Mesenchymal Stem Cells Transplantations Could Not Enhance Therapeutic Effect Compared with Single Transplantation in Systemic Lupus ErythematosusDandan Wang0Kentaro Akiyama1Huayong Zhang2Takayoshi Yamaza3Xia Li4Xuebing Feng5Hong Wang6Bingzhu Hua7Bujun Liu8Huji Xu9Wanjun Chen10Songtao Shi11Lingyun Sun12Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, ChinaCenter for Craniofacial Molecular Biology, University of Southern California School of Dentistry, Los Angeles, CA 90033, USADepartment of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, ChinaCenter for Craniofacial Molecular Biology, University of Southern California School of Dentistry, Los Angeles, CA 90033, USADepartment of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, ChinaDepartment of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, ChinaDepartment of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, ChinaDepartment of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, ChinaDepartment of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, ChinaDepartment of Rheumatology and Immunology, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, ChinaMucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MA 20892-2190, USACenter for Craniofacial Molecular Biology, University of Southern California School of Dentistry, Los Angeles, CA 90033, USADepartment of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, ChinaThe clinical trial of allogenic mesenchymal stem cells (MSCs) transplantation for refractory SLE patients has shown significant safety and efficacy profiles. However, the optimum frequency of the MSCs transplantation (MSCT) is unknown. This study was undertaken to observe whether double transplantations of MSCs is superior to single transplantation. Fifty-eight refractory SLE patients were enrolled in this study, in which 30 were randomly given single MSCT, and the other 28 were given double MSCT. Patients were followed up for rates of survival, disease remission, and relapse, as well as transplantation-related adverse events. SLE disease activity index (SLEDAI) and serologic features were evaluated. Our results showed that no remarkable differences between single and double allogenic MSCT were found in terms of disease remission and relapse, amelioration of disease activity, and serum indexes in an SLE clinical trial with more than one year followup. This study demonstrated that single MSCs transplantation at the dose of one million MSCs per kilogram of body weight was sufficient to induce disease remission for refractory SLE patients.http://dx.doi.org/10.1155/2012/273291 |
| spellingShingle | Dandan Wang Kentaro Akiyama Huayong Zhang Takayoshi Yamaza Xia Li Xuebing Feng Hong Wang Bingzhu Hua Bujun Liu Huji Xu Wanjun Chen Songtao Shi Lingyun Sun Double Allogenic Mesenchymal Stem Cells Transplantations Could Not Enhance Therapeutic Effect Compared with Single Transplantation in Systemic Lupus Erythematosus Clinical and Developmental Immunology |
| title | Double Allogenic Mesenchymal Stem Cells Transplantations Could Not
Enhance Therapeutic Effect Compared with Single Transplantation in Systemic Lupus Erythematosus |
| title_full | Double Allogenic Mesenchymal Stem Cells Transplantations Could Not
Enhance Therapeutic Effect Compared with Single Transplantation in Systemic Lupus Erythematosus |
| title_fullStr | Double Allogenic Mesenchymal Stem Cells Transplantations Could Not
Enhance Therapeutic Effect Compared with Single Transplantation in Systemic Lupus Erythematosus |
| title_full_unstemmed | Double Allogenic Mesenchymal Stem Cells Transplantations Could Not
Enhance Therapeutic Effect Compared with Single Transplantation in Systemic Lupus Erythematosus |
| title_short | Double Allogenic Mesenchymal Stem Cells Transplantations Could Not
Enhance Therapeutic Effect Compared with Single Transplantation in Systemic Lupus Erythematosus |
| title_sort | double allogenic mesenchymal stem cells transplantations could not enhance therapeutic effect compared with single transplantation in systemic lupus erythematosus |
| url | http://dx.doi.org/10.1155/2012/273291 |
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