Enhanced effects of slowly co-released TGF-β3 and BMP-2 from biomimetic calcium phosphate-coated silk fibroin scaffolds in the repair of osteochondral defects

Enhanced effects of slowly co-released TGF-β3 and BMP-2 from biomimetic calcium phosphate-coated silk fibroin scaffolds in the repair of osteochondral defects

Abstract Bioactive agents have demonstrated regenerative potential for cell-free bone tissue engineering. Nevertheless, certain challenges persist, including ineffective delivery methods and confined therapeutic potency. Here, we demonstrated that the biomimetic calcium phosphate coating system (Bio...

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Bibliographic Details
Main Authors: Jiping Chen, Yanyi Wang, Tianyi Tang, Baochao Li, Banani Kundu, Subhas C. Kundu, Rui L. Reis, Xingnan Lin, Huang Li
Format: Article
Language:English
Published: BMC 2024-07-01
Series:Journal of Nanobiotechnology
Subjects:
Silk fibroin
Biomimetic calcium phosphate coating
Drug delivery
Slow release
Osteochondral defect
Tissue engineering
Online Access:https://doi.org/10.1186/s12951-024-02712-0
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