Is There a Relationship between Ovarian Epithelial Dysplasia and Infertility?
Aim. Ovarian epithelial dysplasia was initially described in material from prophylactic oophorectomies performed in patients at genetic risk of ovarian cancer. Similar histopathological abnormalities have been revealed after ovulation stimulation. Since infertility is also a risk factor for ovarian...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Obstetrics and Gynecology International |
| Online Access: | http://dx.doi.org/10.1155/2012/429085 |
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| author | Gautier Chene Frédérique Penault-Llorca Anne Tardieu Anne Cayre Nicole Lagarde Patricia Jaffeux Bruno Aublet-Cuvelier Pierre Dechelotte Bertrand Felloni Jean-Luc Pouly Jacques Dauplat |
| author_facet | Gautier Chene Frédérique Penault-Llorca Anne Tardieu Anne Cayre Nicole Lagarde Patricia Jaffeux Bruno Aublet-Cuvelier Pierre Dechelotte Bertrand Felloni Jean-Luc Pouly Jacques Dauplat |
| author_sort | Gautier Chene |
| collection | DOAJ |
| description | Aim. Ovarian epithelial dysplasia was initially described in material from prophylactic oophorectomies performed in patients at genetic risk of ovarian cancer. Similar histopathological abnormalities have been revealed after ovulation stimulation. Since infertility is also a risk factor for ovarian neoplasia, the aim of this study was to study the relationship between infertility and ovarian dysplasia. Methods. We blindly reviewed 127 histopathological slides of adnexectomies or ovarian cystectomies according to three groups—an exposed group to ovulation induction (n = 30), an infertile group without stimulation (n = 35), and a spontaneously fertile control group (n = 62)—in order to design an eleven histopathological criteria scoring system. Results. The ovarian dysplasia score was significantly higher in exposed group whereas dysplasia score was low in infertile and control groups (resp., 8.21 in exposed group, 3.69 for infertile patients, and 3.62 for the controls). In the subgroup with refractory infertility there was a trend towards a more severe dysplasia score (8.53 in ovulation induction group and 5.1 in infertile group). Conclusion. These results raise questions as to the responsibility of drugs used to induce ovulation and/or infertility itself in the genesis of ovarian epithelial dysplasia. |
| format | Article |
| id | doaj-art-027c9aa8f05543a6ada9a863b450ab36 |
| institution | Kabale University |
| issn | 1687-9589 1687-9597 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Obstetrics and Gynecology International |
| spelling | doaj-art-027c9aa8f05543a6ada9a863b450ab362025-02-03T05:50:55ZengWileyObstetrics and Gynecology International1687-95891687-95972012-01-01201210.1155/2012/429085429085Is There a Relationship between Ovarian Epithelial Dysplasia and Infertility?Gautier Chene0Frédérique Penault-Llorca1Anne Tardieu2Anne Cayre3Nicole Lagarde4Patricia Jaffeux5Bruno Aublet-Cuvelier6Pierre Dechelotte7Bertrand Felloni8Jean-Luc Pouly9Jacques Dauplat10Department of Histopathology, Centre Jean Perrin, Clermont-Ferrand 63000, FranceDepartment of Histopathology, Centre Jean Perrin, Clermont-Ferrand 63000, FranceDepartment of Histopathology, Centre Jean Perrin, Clermont-Ferrand 63000, FranceDepartment of Histopathology, Centre Jean Perrin, Clermont-Ferrand 63000, FranceDepartment of Histopathology, Centre Jean Perrin, Clermont-Ferrand 63000, FranceDepartment of Medical Information, CHU Clermont-Ferrand, Clermont-Ferrand 63000, FranceDepartment of Medical Information, CHU Clermont-Ferrand, Clermont-Ferrand 63000, FranceDepartment of Histopathology, CHU, Clermont-Ferrand 63000, FranceDepartment of Obstetric, Gynecology and Reproductive Medicine, CHU St. Etienne, Saint-Etienne 42000, FranceDepartment of Obstetric, Gynecology & Reproductive Medicine, CHU Clermont-Ferrand, Clermont-Ferrand 63000, FranceDepartment of Surgery, Centre Jean Perrin, Clermont-Ferrand 63000, FranceAim. Ovarian epithelial dysplasia was initially described in material from prophylactic oophorectomies performed in patients at genetic risk of ovarian cancer. Similar histopathological abnormalities have been revealed after ovulation stimulation. Since infertility is also a risk factor for ovarian neoplasia, the aim of this study was to study the relationship between infertility and ovarian dysplasia. Methods. We blindly reviewed 127 histopathological slides of adnexectomies or ovarian cystectomies according to three groups—an exposed group to ovulation induction (n = 30), an infertile group without stimulation (n = 35), and a spontaneously fertile control group (n = 62)—in order to design an eleven histopathological criteria scoring system. Results. The ovarian dysplasia score was significantly higher in exposed group whereas dysplasia score was low in infertile and control groups (resp., 8.21 in exposed group, 3.69 for infertile patients, and 3.62 for the controls). In the subgroup with refractory infertility there was a trend towards a more severe dysplasia score (8.53 in ovulation induction group and 5.1 in infertile group). Conclusion. These results raise questions as to the responsibility of drugs used to induce ovulation and/or infertility itself in the genesis of ovarian epithelial dysplasia.http://dx.doi.org/10.1155/2012/429085 |
| spellingShingle | Gautier Chene Frédérique Penault-Llorca Anne Tardieu Anne Cayre Nicole Lagarde Patricia Jaffeux Bruno Aublet-Cuvelier Pierre Dechelotte Bertrand Felloni Jean-Luc Pouly Jacques Dauplat Is There a Relationship between Ovarian Epithelial Dysplasia and Infertility? Obstetrics and Gynecology International |
| title | Is There a Relationship between Ovarian Epithelial Dysplasia and Infertility? |
| title_full | Is There a Relationship between Ovarian Epithelial Dysplasia and Infertility? |
| title_fullStr | Is There a Relationship between Ovarian Epithelial Dysplasia and Infertility? |
| title_full_unstemmed | Is There a Relationship between Ovarian Epithelial Dysplasia and Infertility? |
| title_short | Is There a Relationship between Ovarian Epithelial Dysplasia and Infertility? |
| title_sort | is there a relationship between ovarian epithelial dysplasia and infertility |
| url | http://dx.doi.org/10.1155/2012/429085 |
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