Design and screening of novel 1,2,4-Triazole-3-thione derivatives as DCN1 inhibitors for anticardiac fibrosis based on 3D-QSAR modeling and molecular dynamics
ObjectiveDefective in cullin neddylation 1 (DCN1) plays a pivotal role in anticardiac fibrosis by interacting with UBC12 and catalyzing cullin neddylation, which activates cullin-RING E3 ligases (CRLs). As a key modulator of anticardiac fibrosis, DCN1 has emerged as an attractive target for therapeu...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1590711/full |
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