Placental Mesenchymal Dysplasia: A Case Report
Introduction. A rare case of histologically proven placental mesenchymal dysplasia (PMD) with fetal omphalocele in a 22-year-old patient is reported. Material and Methods. Antenatal ultrasound of this patient showed hydropic placenta with a live fetus of 17 weeks period of gestation associated with...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Obstetrics and Gynecology |
| Online Access: | http://dx.doi.org/10.1155/2012/202797 |
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| author | Rachna Agarwal Ritu Khatuja Lipi Sharma Alpana Singh |
| author_facet | Rachna Agarwal Ritu Khatuja Lipi Sharma Alpana Singh |
| author_sort | Rachna Agarwal |
| collection | DOAJ |
| description | Introduction. A rare case of histologically proven placental mesenchymal dysplasia (PMD) with fetal omphalocele in a 22-year-old patient is reported. Material and Methods. Antenatal ultrasound of this patient showed hydropic placenta with a live fetus of 17 weeks period of gestation associated with omphalocele. Cordocentesis detected the diploid karyotype of the fetus. Patient, when prognosticated, choose to terminate the pregnancy in view of high incidence of fetal and placental anomalies. Subsequent histopathological examination of placenta established the diagnosis to be placental mesenchymal dysplasia. Conclusion. On clinical and ultrasonic grounds, suspicion of P.M.D. arises when hydropic placenta with a live fetus presents in second trimester of pregnancy. Cordocentesis can detect the diploid karyotype of the fetus in such cases. As this condition is prognostically better than triploid partial mole, continuation of pregnancy can sometimes be considered after through antenatal screening and patient counseling. However, a definite diagnosis of P.M.D. is made only on placental histology by absence of trophoblast hyperplasia and trophoblastic inclusions. |
| format | Article |
| id | doaj-art-0274473fa5cb4b6f957432e4d15dd5ac |
| institution | Kabale University |
| issn | 2090-6684 2090-6692 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Obstetrics and Gynecology |
| spelling | doaj-art-0274473fa5cb4b6f957432e4d15dd5ac2025-02-03T01:22:04ZengWileyCase Reports in Obstetrics and Gynecology2090-66842090-66922012-01-01201210.1155/2012/202797202797Placental Mesenchymal Dysplasia: A Case ReportRachna Agarwal0Ritu Khatuja1Lipi Sharma2Alpana Singh3Department of Obstetrics & Gynaecology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi 110095, IndiaDepartment of Obstetrics & Gynaecology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi 110095, IndiaDepartment of Obstetrics & Gynaecology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi 110095, IndiaDepartment of Obstetrics & Gynaecology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi 110095, IndiaIntroduction. A rare case of histologically proven placental mesenchymal dysplasia (PMD) with fetal omphalocele in a 22-year-old patient is reported. Material and Methods. Antenatal ultrasound of this patient showed hydropic placenta with a live fetus of 17 weeks period of gestation associated with omphalocele. Cordocentesis detected the diploid karyotype of the fetus. Patient, when prognosticated, choose to terminate the pregnancy in view of high incidence of fetal and placental anomalies. Subsequent histopathological examination of placenta established the diagnosis to be placental mesenchymal dysplasia. Conclusion. On clinical and ultrasonic grounds, suspicion of P.M.D. arises when hydropic placenta with a live fetus presents in second trimester of pregnancy. Cordocentesis can detect the diploid karyotype of the fetus in such cases. As this condition is prognostically better than triploid partial mole, continuation of pregnancy can sometimes be considered after through antenatal screening and patient counseling. However, a definite diagnosis of P.M.D. is made only on placental histology by absence of trophoblast hyperplasia and trophoblastic inclusions.http://dx.doi.org/10.1155/2012/202797 |
| spellingShingle | Rachna Agarwal Ritu Khatuja Lipi Sharma Alpana Singh Placental Mesenchymal Dysplasia: A Case Report Case Reports in Obstetrics and Gynecology |
| title | Placental Mesenchymal Dysplasia: A Case Report |
| title_full | Placental Mesenchymal Dysplasia: A Case Report |
| title_fullStr | Placental Mesenchymal Dysplasia: A Case Report |
| title_full_unstemmed | Placental Mesenchymal Dysplasia: A Case Report |
| title_short | Placental Mesenchymal Dysplasia: A Case Report |
| title_sort | placental mesenchymal dysplasia a case report |
| url | http://dx.doi.org/10.1155/2012/202797 |
| work_keys_str_mv | AT rachnaagarwal placentalmesenchymaldysplasiaacasereport AT ritukhatuja placentalmesenchymaldysplasiaacasereport AT lipisharma placentalmesenchymaldysplasiaacasereport AT alpanasingh placentalmesenchymaldysplasiaacasereport |