Low-grade astrocytoma: surgical outcomes in eloquent versus non-eloquent brain areas
A retrospective study of 81 patients with low-grade astrocytoma (LGA) comparing the efficacy of aggressive versus less aggressive surgery in eloquent and non-eloquent brain areas was conducted. Extent of surgical resection was analyzed to assess overall survival (OS) and progression- free survival (...
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações
2013-01-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013000100007&lng=en&tlng=en |
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| author | André de Macedo Bianco Flavio Key Miura Carlos Clara Jose Reynaldo W. Almeida Clemar Correa da Silva Manoel Jacobsen Teixeira Suely K. Nagahashi Marie |
| author_facet | André de Macedo Bianco Flavio Key Miura Carlos Clara Jose Reynaldo W. Almeida Clemar Correa da Silva Manoel Jacobsen Teixeira Suely K. Nagahashi Marie |
| author_sort | André de Macedo Bianco |
| collection | DOAJ |
| description | A retrospective study of 81 patients with low-grade astrocytoma (LGA) comparing the efficacy of aggressive versus less aggressive surgery in eloquent and non-eloquent brain areas was conducted. Extent of surgical resection was analyzed to assess overall survival (OS) and progression- free survival (PFS). Degree of tumor resection was classified as gross total resection (GTR), subtotal resection (STR) or biopsy. GTR, STR and biopsy in patients with tumors in non-eloquent areas were performed in 31, 48 and 21% subjects, whereas in patients with tumors in eloquent areas resections were 22.5, 35 and 42.5%. Overall survival was 4.7 and 1.9 years in patients with tumors in non-eloquent brain areas submitted to GTR/STR and biopsy (p=0.013), whereas overall survival among patients with tumors in eloquent area was 4.5 and 2.1 years (p=0.33). Improved outcome for adult patients with LGA is predicted by more aggressive surgery in both eloquent and non-eloquent brain areas. |
| format | Article |
| id | doaj-art-02735eb2cf414bd18b0b7dfdabea6834 |
| institution | Kabale University |
| issn | 1678-4227 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-02735eb2cf414bd18b0b7dfdabea68342025-08-20T03:54:25ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272013-01-017113134S0004-282X2013000100007Low-grade astrocytoma: surgical outcomes in eloquent versus non-eloquent brain areasAndré de Macedo Bianco0Flavio Key Miura1Carlos Clara2Jose Reynaldo W. Almeida3Clemar Correa da Silva4Manoel Jacobsen Teixeira5Suely K. Nagahashi Marie6Universidade de São PauloUniversidade de São PauloHospital de Câncer de BarretosHospital de Câncer de BarretosUniversidade de São PauloUniversidade de São PauloUniversidade de São PauloA retrospective study of 81 patients with low-grade astrocytoma (LGA) comparing the efficacy of aggressive versus less aggressive surgery in eloquent and non-eloquent brain areas was conducted. Extent of surgical resection was analyzed to assess overall survival (OS) and progression- free survival (PFS). Degree of tumor resection was classified as gross total resection (GTR), subtotal resection (STR) or biopsy. GTR, STR and biopsy in patients with tumors in non-eloquent areas were performed in 31, 48 and 21% subjects, whereas in patients with tumors in eloquent areas resections were 22.5, 35 and 42.5%. Overall survival was 4.7 and 1.9 years in patients with tumors in non-eloquent brain areas submitted to GTR/STR and biopsy (p=0.013), whereas overall survival among patients with tumors in eloquent area was 4.5 and 2.1 years (p=0.33). Improved outcome for adult patients with LGA is predicted by more aggressive surgery in both eloquent and non-eloquent brain areas.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013000100007&lng=en&tlng=enastrocitomaanálise de sobrevidaneurocirurgia |
| spellingShingle | André de Macedo Bianco Flavio Key Miura Carlos Clara Jose Reynaldo W. Almeida Clemar Correa da Silva Manoel Jacobsen Teixeira Suely K. Nagahashi Marie Low-grade astrocytoma: surgical outcomes in eloquent versus non-eloquent brain areas Arquivos de Neuro-Psiquiatria astrocitoma análise de sobrevida neurocirurgia |
| title | Low-grade astrocytoma: surgical outcomes in eloquent versus non-eloquent brain areas |
| title_full | Low-grade astrocytoma: surgical outcomes in eloquent versus non-eloquent brain areas |
| title_fullStr | Low-grade astrocytoma: surgical outcomes in eloquent versus non-eloquent brain areas |
| title_full_unstemmed | Low-grade astrocytoma: surgical outcomes in eloquent versus non-eloquent brain areas |
| title_short | Low-grade astrocytoma: surgical outcomes in eloquent versus non-eloquent brain areas |
| title_sort | low grade astrocytoma surgical outcomes in eloquent versus non eloquent brain areas |
| topic | astrocitoma análise de sobrevida neurocirurgia |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013000100007&lng=en&tlng=en |
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