Comparison of triglyceride-glucose index and triglyceride-glucose related indexes in predicting cardiovascular disease incidence among populations with cardiovascular-kidney-metabolic syndrome stages 0-3: a nationwide prospective cohort study
BackgroundThe association of the triglyceride glucose (TyG) index and related TyG metrics with obesity indices has been demonstrated to correlate with the incidence of cardiovascular disease (CVD). Nonetheless, this relationship has not been thoroughly investigated in patients with cardiovascular-ki...
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1562135/full |
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| author | Qingsong Mao Nianzhou Liu Tian Xiong Xinyi Wang Xinling Tian Yuzhe Kong |
| author_facet | Qingsong Mao Nianzhou Liu Tian Xiong Xinyi Wang Xinling Tian Yuzhe Kong |
| author_sort | Qingsong Mao |
| collection | DOAJ |
| description | BackgroundThe association of the triglyceride glucose (TyG) index and related TyG metrics with obesity indices has been demonstrated to correlate with the incidence of cardiovascular disease (CVD). Nonetheless, this relationship has not been thoroughly investigated in patients with cardiovascular-kidney-metabolic (CKM) syndrome stages 0-3.MethodsThis study involved 7364 participants from the China Health and Retirement Longitudinal Study (CHARLS). Cox risk regression and restricted cubic spline (RCS) regression were used to analyze the correlation between the TyG index and related TyG indicators and the incidence rate of cardiovascular disease. To compare predictive performance, time-dependent Harrell’s C-indices, net reclassification index and integrated discrimination improvement were conducted.ResultsResearch shows that the TyG index and all TyG-related indexes can predict the incidence rate of CVD. RCS regression analysis showed that all indicators were linearly related to the incidence rate of CVD. The linear relationship between TyG and waist circumference (TyG-WC) or waist-to-height ratio (TyG-WHtR) still exists in CKM stages 1, 2, and 3. Compared with the TyG index (C-index: 0.611, p<0.001) and TyG-BMI (C-coefficient: 0.616, p<0.001), TyG-WC (C-index: 0.621, p<0.001) and TyG-WHtR (C-index: 0.621, p<0.001) have better effects on predicting the incidence rate of CVD.ConclusionBoth the TyG index and the TyG-related index are independent predictors of the incidence rate of CVD in patients with CKM syndrome stage 0-3. Importantly, TyG-WC and TyG-WHtR have a better predictive effect. |
| format | Article |
| id | doaj-art-0270695501ee4e10bdb040d90b07f489 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-0270695501ee4e10bdb040d90b07f4892025-08-22T04:10:37ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-08-011610.3389/fendo.2025.15621351562135Comparison of triglyceride-glucose index and triglyceride-glucose related indexes in predicting cardiovascular disease incidence among populations with cardiovascular-kidney-metabolic syndrome stages 0-3: a nationwide prospective cohort studyQingsong Mao0Nianzhou Liu1Tian Xiong2Xinyi Wang3Xinling Tian4Yuzhe Kong5Hepatobiliary Pancreatic Surgery, Banan Hospital Affiliated of Chongqing Medical University, Chongqing, ChinaHepatobiliary Pancreatic Surgery, Banan Hospital Affiliated of Chongqing Medical University, Chongqing, ChinaXiangya School of Medicine, Central South University, Changsha, ChinaXiangya School of Medicine, Central South University, Changsha, ChinaXiangya School of Medicine, Central South University, Changsha, ChinaXiangya School of Medicine, Central South University, Changsha, ChinaBackgroundThe association of the triglyceride glucose (TyG) index and related TyG metrics with obesity indices has been demonstrated to correlate with the incidence of cardiovascular disease (CVD). Nonetheless, this relationship has not been thoroughly investigated in patients with cardiovascular-kidney-metabolic (CKM) syndrome stages 0-3.MethodsThis study involved 7364 participants from the China Health and Retirement Longitudinal Study (CHARLS). Cox risk regression and restricted cubic spline (RCS) regression were used to analyze the correlation between the TyG index and related TyG indicators and the incidence rate of cardiovascular disease. To compare predictive performance, time-dependent Harrell’s C-indices, net reclassification index and integrated discrimination improvement were conducted.ResultsResearch shows that the TyG index and all TyG-related indexes can predict the incidence rate of CVD. RCS regression analysis showed that all indicators were linearly related to the incidence rate of CVD. The linear relationship between TyG and waist circumference (TyG-WC) or waist-to-height ratio (TyG-WHtR) still exists in CKM stages 1, 2, and 3. Compared with the TyG index (C-index: 0.611, p<0.001) and TyG-BMI (C-coefficient: 0.616, p<0.001), TyG-WC (C-index: 0.621, p<0.001) and TyG-WHtR (C-index: 0.621, p<0.001) have better effects on predicting the incidence rate of CVD.ConclusionBoth the TyG index and the TyG-related index are independent predictors of the incidence rate of CVD in patients with CKM syndrome stage 0-3. Importantly, TyG-WC and TyG-WHtR have a better predictive effect.https://www.frontiersin.org/articles/10.3389/fendo.2025.1562135/fullcardiovascular kidney metabolic syndromecardiovascular diseasetriglyceride glucose indextriglyceride glucose-related indexCHARLS |
| spellingShingle | Qingsong Mao Nianzhou Liu Tian Xiong Xinyi Wang Xinling Tian Yuzhe Kong Comparison of triglyceride-glucose index and triglyceride-glucose related indexes in predicting cardiovascular disease incidence among populations with cardiovascular-kidney-metabolic syndrome stages 0-3: a nationwide prospective cohort study Frontiers in Endocrinology cardiovascular kidney metabolic syndrome cardiovascular disease triglyceride glucose index triglyceride glucose-related index CHARLS |
| title | Comparison of triglyceride-glucose index and triglyceride-glucose related indexes in predicting cardiovascular disease incidence among populations with cardiovascular-kidney-metabolic syndrome stages 0-3: a nationwide prospective cohort study |
| title_full | Comparison of triglyceride-glucose index and triglyceride-glucose related indexes in predicting cardiovascular disease incidence among populations with cardiovascular-kidney-metabolic syndrome stages 0-3: a nationwide prospective cohort study |
| title_fullStr | Comparison of triglyceride-glucose index and triglyceride-glucose related indexes in predicting cardiovascular disease incidence among populations with cardiovascular-kidney-metabolic syndrome stages 0-3: a nationwide prospective cohort study |
| title_full_unstemmed | Comparison of triglyceride-glucose index and triglyceride-glucose related indexes in predicting cardiovascular disease incidence among populations with cardiovascular-kidney-metabolic syndrome stages 0-3: a nationwide prospective cohort study |
| title_short | Comparison of triglyceride-glucose index and triglyceride-glucose related indexes in predicting cardiovascular disease incidence among populations with cardiovascular-kidney-metabolic syndrome stages 0-3: a nationwide prospective cohort study |
| title_sort | comparison of triglyceride glucose index and triglyceride glucose related indexes in predicting cardiovascular disease incidence among populations with cardiovascular kidney metabolic syndrome stages 0 3 a nationwide prospective cohort study |
| topic | cardiovascular kidney metabolic syndrome cardiovascular disease triglyceride glucose index triglyceride glucose-related index CHARLS |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1562135/full |
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