Collagen signaling and matrix stiffness regulate multipotency in glandular epithelial stem cells in mice

Collagen signaling and matrix stiffness regulate multipotency in glandular epithelial stem cells in mice

Abstract Glandular epithelia, including mammary gland (MG) and prostate, are composed of luminal and basal cells. During embryonic development, glandular epithelia arise from multipotent stem cells (SCs) that are replaced after birth by unipotent basal and unipotent luminal SCs. Different conditions...

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Bibliographic Details
Main Authors: Chen Jiang, Alessia Centonze, Yura Song, Antonius Chrisnandy, Elisavet Tika, Saba Rezakhani, Zahra Zahedi, Gaëlle Bouvencourt, Christine Dubois, Alexandra Van Keymeulen, Matthias Lütolf, Alejandro Sifrim, Cédric Blanpain
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54843-5
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