Knockdown of IGF2BP2 overcomes cisplatin-resistance in lung cancer through downregulating Spon2 gene

Knockdown of IGF2BP2 overcomes cisplatin-resistance in lung cancer through downregulating Spon2 gene

Abstract Background Cisplatin (DDP) resistance has long posed a challenge in the clinical treatment of lung cancer (LC). Insulin-like growth factor 2 binding protein 2 (IGF2BP2) has been identified as an oncogenic factor in LC, whereas its specific role in DDP resistance in LC remains unclear. Resul...

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Bibliographic Details
Main Authors: Shilei Zhang, Ting Dou, Hong Li, Hongfang Yu, Wei Zhang, Liping Sun, Jingwen Yang, Zhenfei Wang, Hao Yang
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Hereditas
Subjects:
Lung cancer
N6-methyladosine RNA methylation
Cisplatin
Resistance
IGF2BP2
Online Access:https://doi.org/10.1186/s41065-024-00360-w
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