The reaction specificity of mammalian ALOX15B orthologs does not depend on the evolutionary ranking of the animals

The reaction specificity of mammalian ALOX15B orthologs does not depend on the evolutionary ranking of the animals

Arachidonic acid lipoxygenases (ALOXs) play important roles in cell differentiation and in the pathogenesis of cardiovascular, hyperproliferative, neurodegenerative, and metabolic diseases. The human genome involves six intact ALOX genes and knockout studies of the corresponding mouse orthologs indi...

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Bibliographic Details
Main Authors: Eda Gündem, Sabine Stehling, Astrid Borchert, Hartmut Kuhn
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Journal of Lipid Research
Subjects:
eicosanoids
lipid peroxidation
oxidative stress
enzyme evolution
ferroptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227525000288
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