Corn Oil Supplementation Enhances Locomotor Performance and Mitochondrial Function in <i>Drosophila melanogaster</i>
Polyunsaturated fatty acids are vital for brain health, supporting cognitive development and helping to prevent neurodegenerative diseases. Since the body cannot produce them, they must be obtained through food. This study aimed to assess the effects of corn oil on the behavior and biochemical param...
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2025-07-01
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| author | Jadyellen Rondon Silva Thiago Henrique Oliveira Alves Eric Bruno Silva Santos Marylu Mardegan Lima Giulia Covolo Spegiorim Carlos Antônio Couto-Lima Luciane Carla Alberici Marcos José Jacinto Anderson Oliveira Souza |
| author_facet | Jadyellen Rondon Silva Thiago Henrique Oliveira Alves Eric Bruno Silva Santos Marylu Mardegan Lima Giulia Covolo Spegiorim Carlos Antônio Couto-Lima Luciane Carla Alberici Marcos José Jacinto Anderson Oliveira Souza |
| author_sort | Jadyellen Rondon Silva |
| collection | DOAJ |
| description | Polyunsaturated fatty acids are vital for brain health, supporting cognitive development and helping to prevent neurodegenerative diseases. Since the body cannot produce them, they must be obtained through food. This study aimed to assess the effects of corn oil on the behavior and biochemical parameters of <i>Drosophila melanogaster</i>. The flies were fed a diet supplemented with different concentrations of corn oil from the larval stage until the fifth day of adulthood. A diet containing corn oil (37.8 mg/mL of linoleic acid) reduced mortality under starvation conditions and enhanced locomotor performance (<i>p</i> < 0.01). Biochemical analyses revealed increased levels of glutathione (<i>p</i> < 0.001), citrate synthase activity (<i>p</i> < 0.05), and mitochondrial phosphorylation (<i>p</i> < 0.05), indicating a potential boost in energy metabolism. Conversely, a decrease in acetylcholinesterase activity (<i>p</i> < 0.05) was observed, suggesting cholinergic modulation. These results demonstrate that corn oil supplementation supports neural health in this animal model, opening pathways for further research into non-pharmacological treatments for neurodegenerative diseases such as Alzheimer’s disease. |
| format | Article |
| id | doaj-art-02564aa036e64b7e8e36c376bfd15ac3 |
| institution | Kabale University |
| issn | 2076-3417 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj-art-02564aa036e64b7e8e36c376bfd15ac32025-08-20T03:50:16ZengMDPI AGApplied Sciences2076-34172025-07-011513760710.3390/app15137607Corn Oil Supplementation Enhances Locomotor Performance and Mitochondrial Function in <i>Drosophila melanogaster</i>Jadyellen Rondon Silva0Thiago Henrique Oliveira Alves1Eric Bruno Silva Santos2Marylu Mardegan Lima3Giulia Covolo Spegiorim4Carlos Antônio Couto-Lima5Luciane Carla Alberici6Marcos José Jacinto7Anderson Oliveira Souza8Mitochondrial Metabolism and Neurotoxicology Laboratory, Department of Chemistry, Institute of Chemistry, Federal University of Mato Grosso, Cuiabá 79070-900, BrazilMitochondrial Metabolism and Neurotoxicology Laboratory, Department of Chemistry, Institute of Chemistry, Federal University of Mato Grosso, Cuiabá 79070-900, BrazilLaboratory of Ecology and Microbial Biotechnology, Institute of Biosciences, Federal University of Mato Grosso, Cuiabá 79070-900, BrazilDepartment of Biomolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, São Paulo 05508-220, BrazilDepartment of Biomolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, São Paulo 05508-220, BrazilOncoFly Laboratory, Department of Clinical Analysis, São Paulo State University, Araraquara 14800-903, BrazilDepartment of Biomolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, São Paulo 05508-220, BrazilLaboratory of Nanomaterials and Catalysis, Department of Chemistry, Institute of Chemistry, Federal University of Mato Grosso, Cuiabá 79070-900, BrazilMitochondrial Metabolism and Neurotoxicology Laboratory, Department of Chemistry, Institute of Chemistry, Federal University of Mato Grosso, Cuiabá 79070-900, BrazilPolyunsaturated fatty acids are vital for brain health, supporting cognitive development and helping to prevent neurodegenerative diseases. Since the body cannot produce them, they must be obtained through food. This study aimed to assess the effects of corn oil on the behavior and biochemical parameters of <i>Drosophila melanogaster</i>. The flies were fed a diet supplemented with different concentrations of corn oil from the larval stage until the fifth day of adulthood. A diet containing corn oil (37.8 mg/mL of linoleic acid) reduced mortality under starvation conditions and enhanced locomotor performance (<i>p</i> < 0.01). Biochemical analyses revealed increased levels of glutathione (<i>p</i> < 0.001), citrate synthase activity (<i>p</i> < 0.05), and mitochondrial phosphorylation (<i>p</i> < 0.05), indicating a potential boost in energy metabolism. Conversely, a decrease in acetylcholinesterase activity (<i>p</i> < 0.05) was observed, suggesting cholinergic modulation. These results demonstrate that corn oil supplementation supports neural health in this animal model, opening pathways for further research into non-pharmacological treatments for neurodegenerative diseases such as Alzheimer’s disease.https://www.mdpi.com/2076-3417/15/13/7607<i>Drosophila melanogaster</i>corn oilbiochemical and behavioral parametersfunctional food |
| spellingShingle | Jadyellen Rondon Silva Thiago Henrique Oliveira Alves Eric Bruno Silva Santos Marylu Mardegan Lima Giulia Covolo Spegiorim Carlos Antônio Couto-Lima Luciane Carla Alberici Marcos José Jacinto Anderson Oliveira Souza Corn Oil Supplementation Enhances Locomotor Performance and Mitochondrial Function in <i>Drosophila melanogaster</i> Applied Sciences <i>Drosophila melanogaster</i> corn oil biochemical and behavioral parameters functional food |
| title | Corn Oil Supplementation Enhances Locomotor Performance and Mitochondrial Function in <i>Drosophila melanogaster</i> |
| title_full | Corn Oil Supplementation Enhances Locomotor Performance and Mitochondrial Function in <i>Drosophila melanogaster</i> |
| title_fullStr | Corn Oil Supplementation Enhances Locomotor Performance and Mitochondrial Function in <i>Drosophila melanogaster</i> |
| title_full_unstemmed | Corn Oil Supplementation Enhances Locomotor Performance and Mitochondrial Function in <i>Drosophila melanogaster</i> |
| title_short | Corn Oil Supplementation Enhances Locomotor Performance and Mitochondrial Function in <i>Drosophila melanogaster</i> |
| title_sort | corn oil supplementation enhances locomotor performance and mitochondrial function in i drosophila melanogaster i |
| topic | <i>Drosophila melanogaster</i> corn oil biochemical and behavioral parameters functional food |
| url | https://www.mdpi.com/2076-3417/15/13/7607 |
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