ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6-specific nanobody restricts M. tuberculosis growth in macrophages

ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6-specific nanobody restricts M. tuberculosis growth in macrophages

Mycobacterium tuberculosis (Mtb) is known to survive within macrophages by compromising the integrity of the phagosomal compartment in which it resides. This activity primarily relies on the ESX-1 secretion system, predominantly involving the protein duo ESAT-6 and CFP-10. CFP-10 likely acts as a ch...

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Bibliographic Details
Main Authors: Timothy A Bates, Mila Trank-Greene, Xammy Huu Wrynla, Aidan Anastas, Sintayehu K Gurmessa, Ilaria R Merutka, Shandee D Dixon, Anthony Shumate, Abigail R Groncki, Matthew AH Parson, Jessica R Ingram, Eric Barklis, John E Burke, Ujwal Shinde, Hidde L Ploegh, Fikadu G Tafesse
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-05-01
Series:eLife
Subjects:
M. tuberculosis
VHH
Nanobody
ESAT-6
CFP-10
biochemistry
Online Access:https://elifesciences.org/articles/91930
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