Efficacy and safety of Coccinia grandis (L.) Voigt on blood glucose and lipid profile: An updated systematic review and meta-analysis
Introduction: Coccinia grandis has been shown to improve blood glucose and lipids. The results of earlier clinical studies on the effects of C. grandis on blood sugar and lipid profile are debatable. This meta-analysis aimed to evaluate, using randomized controlled trials (RCTs), the effects of cons...
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Shahrekord University of Medical Sciences
2024-07-01
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| Series: | Journal of HerbMed Pharmacology |
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| Online Access: | https://herbmedpharmacol.com/PDF/jhp-13-342.pdf |
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| author | Wiraphol Phimarn Chatmanee Taengthonglang Bunleu Sungthong |
| author_facet | Wiraphol Phimarn Chatmanee Taengthonglang Bunleu Sungthong |
| author_sort | Wiraphol Phimarn |
| collection | DOAJ |
| description | Introduction: Coccinia grandis has been shown to improve blood glucose and lipids. The results of earlier clinical studies on the effects of C. grandis on blood sugar and lipid profile are debatable. This meta-analysis aimed to evaluate, using randomized controlled trials (RCTs), the effects of consuming C. grandis on lipid profiles and blood glucose levels. Methods: Thai and English articles by two independent authors were searched in PubMed, ScienceDirect, Scopus, and ThaiJo up to November 2023 for a systematic review. The keywords were developed based on MeSH terms as follows: (Coccinia grandis OR Coccinia cordifolia OR Coccinia indica) AND (fasting blood glucose OR FBS OR fasting plasma glucose OR FPG OR HbA1C OR postprandial glucose OR PPG OR lipid profile OR low-density lipoprotein OR LDL OR high-density lipoprotein OR HDL OR total cholesterol OR TC OR triglyceride OR TG). The Laird and DerSimonian random-effect model was used to pool the findings. Seven trials with 595 individuals and 1–90-day treatments were included. Results: The combined data revealed a noteworthy decline in fasting blood sugar (FBS); standardized mean difference (SMD) by -1.99 mg/dL (P<0.001), 1-hour postprandial glucose (PPG) by -0.99 mg/dL (P<0.001), 2-hour PPG by -0.69 mg/dL (P=0.004) and triglycerides (TG) by -0.46 mg/dL (P=0.001). However, there were no significant differences in hemoglobin A1C (HbA1C), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and total cholesterol (TC). No major intervention side effects were recorded. Conclusion: Our investigation found that C. grandis reduced FBS, PPG, and TG. The treatment’s long-term advantages and safety are unknown. |
| format | Article |
| id | doaj-art-025336c5fcdb4f5fab5b43d15b67177d |
| institution | DOAJ |
| issn | 2345-5004 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Shahrekord University of Medical Sciences |
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| series | Journal of HerbMed Pharmacology |
| spelling | doaj-art-025336c5fcdb4f5fab5b43d15b67177d2025-08-20T02:51:31ZengShahrekord University of Medical SciencesJournal of HerbMed Pharmacology2345-50042024-07-0113334235210.34172/jhp.2024.49331jhp-49331Efficacy and safety of Coccinia grandis (L.) Voigt on blood glucose and lipid profile: An updated systematic review and meta-analysisWiraphol Phimarn0Chatmanee Taengthonglang1Bunleu Sungthong2Social Pharmacy Research Unit, Faculty of Pharmacy, Mahasarakham University, Kantharawichai, Maha Sarakham, Thailand, 44150Pharmacy department, Surin Hospital, Surin, Thailand, 32000Integrative Pharmaceuticals and Innovative of Pharmaceutical Technology Research Unit, Faculty of Pharmacy, Mahasarakham University, Khamriang, Kantharawichai, Maha Sarakham, Thailand, 44150Introduction: Coccinia grandis has been shown to improve blood glucose and lipids. The results of earlier clinical studies on the effects of C. grandis on blood sugar and lipid profile are debatable. This meta-analysis aimed to evaluate, using randomized controlled trials (RCTs), the effects of consuming C. grandis on lipid profiles and blood glucose levels. Methods: Thai and English articles by two independent authors were searched in PubMed, ScienceDirect, Scopus, and ThaiJo up to November 2023 for a systematic review. The keywords were developed based on MeSH terms as follows: (Coccinia grandis OR Coccinia cordifolia OR Coccinia indica) AND (fasting blood glucose OR FBS OR fasting plasma glucose OR FPG OR HbA1C OR postprandial glucose OR PPG OR lipid profile OR low-density lipoprotein OR LDL OR high-density lipoprotein OR HDL OR total cholesterol OR TC OR triglyceride OR TG). The Laird and DerSimonian random-effect model was used to pool the findings. Seven trials with 595 individuals and 1–90-day treatments were included. Results: The combined data revealed a noteworthy decline in fasting blood sugar (FBS); standardized mean difference (SMD) by -1.99 mg/dL (P<0.001), 1-hour postprandial glucose (PPG) by -0.99 mg/dL (P<0.001), 2-hour PPG by -0.69 mg/dL (P=0.004) and triglycerides (TG) by -0.46 mg/dL (P=0.001). However, there were no significant differences in hemoglobin A1C (HbA1C), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and total cholesterol (TC). No major intervention side effects were recorded. Conclusion: Our investigation found that C. grandis reduced FBS, PPG, and TG. The treatment’s long-term advantages and safety are unknown.https://herbmedpharmacol.com/PDF/jhp-13-342.pdfcoccinia grandislipid profilesblood glucosedyslipidemiasmeta-analysissystematic review |
| spellingShingle | Wiraphol Phimarn Chatmanee Taengthonglang Bunleu Sungthong Efficacy and safety of Coccinia grandis (L.) Voigt on blood glucose and lipid profile: An updated systematic review and meta-analysis Journal of HerbMed Pharmacology coccinia grandis lipid profiles blood glucose dyslipidemias meta-analysis systematic review |
| title | Efficacy and safety of Coccinia grandis (L.) Voigt on blood glucose and lipid profile: An updated systematic review and meta-analysis |
| title_full | Efficacy and safety of Coccinia grandis (L.) Voigt on blood glucose and lipid profile: An updated systematic review and meta-analysis |
| title_fullStr | Efficacy and safety of Coccinia grandis (L.) Voigt on blood glucose and lipid profile: An updated systematic review and meta-analysis |
| title_full_unstemmed | Efficacy and safety of Coccinia grandis (L.) Voigt on blood glucose and lipid profile: An updated systematic review and meta-analysis |
| title_short | Efficacy and safety of Coccinia grandis (L.) Voigt on blood glucose and lipid profile: An updated systematic review and meta-analysis |
| title_sort | efficacy and safety of coccinia grandis l voigt on blood glucose and lipid profile an updated systematic review and meta analysis |
| topic | coccinia grandis lipid profiles blood glucose dyslipidemias meta-analysis systematic review |
| url | https://herbmedpharmacol.com/PDF/jhp-13-342.pdf |
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