A novel tertiary lymphoid structure-associated signature accurately predicts patient prognosis and facilitates the selection of personalized treatment strategies for HNSCC
BackgroundHead and neck squamous cell carcinoma (HNSCC) is the most common type of head and neck cancer and is characterized by its aggressive nature and variable prognosis and response to immunotherapy. Tertiary lymphoid structures (TLSs) play crucial roles in creating a favourable immune microenvi...
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Frontiers Media S.A.
2025-03-01
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| author | Jinhao Zhang Lu Zeng Lu Zeng Guobin Song Gaoge Peng Gaoge Peng Zhezheng Chen Zhezheng Chen Yamin Yuan Taowu Chen Tao Zhong Shixi Chen Zhengzhou Luo Zhengzhou Luo Jingang Xiao Jingang Xiao Jingang Xiao Lin Liu Lin Liu Lin Liu |
| author_facet | Jinhao Zhang Lu Zeng Lu Zeng Guobin Song Gaoge Peng Gaoge Peng Zhezheng Chen Zhezheng Chen Yamin Yuan Taowu Chen Tao Zhong Shixi Chen Zhengzhou Luo Zhengzhou Luo Jingang Xiao Jingang Xiao Jingang Xiao Lin Liu Lin Liu Lin Liu |
| author_sort | Jinhao Zhang |
| collection | DOAJ |
| description | BackgroundHead and neck squamous cell carcinoma (HNSCC) is the most common type of head and neck cancer and is characterized by its aggressive nature and variable prognosis and response to immunotherapy. Tertiary lymphoid structures (TLSs) play crucial roles in creating a favourable immune microenvironment to control tumour progression. However, the specific impact of these structures on HNSCC has not been thoroughly studied.MethodsIn this study, a comprehensive review of tertiary lymphoid structures was conducted by analysing 9 TLS-associated genes in a cohort of 871 HNSCC patients. Distinct TLS-related subgroups were identified through unsupervised clustering analysis, and the associated genes were explored. Prognostic genes were identified via univariate Cox and Boruta algorithms, and a novel TLS-related scoring system was developed via the GSVA algorithm.ResultsOur study revealed that patients with higher TLS-related scores had improved overall survival and were more likely to benefit from immunotherapy. Furthermore, we observed a significant negative correlation between sensitivity to traditional chemotherapeutic agents and the TLS-related signature score.ConclusionsOur findings suggest that the TLS-related features of HNSCC patients hold promise as predictive indicators for immunotherapy efficacy and may offer novel insights for tailoring personalized treatment strategies in clinical practice. |
| format | Article |
| id | doaj-art-02528d19070e4328b8d26ec326b8b5a2 |
| institution | DOAJ |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-02528d19070e4328b8d26ec326b8b5a22025-08-20T02:57:17ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-03-011610.3389/fimmu.2025.15518441551844A novel tertiary lymphoid structure-associated signature accurately predicts patient prognosis and facilitates the selection of personalized treatment strategies for HNSCCJinhao Zhang0Lu Zeng1Lu Zeng2Guobin Song3Gaoge Peng4Gaoge Peng5Zhezheng Chen6Zhezheng Chen7Yamin Yuan8Taowu Chen9Tao Zhong10Shixi Chen11Zhengzhou Luo12Zhengzhou Luo13Jingang Xiao14Jingang Xiao15Jingang Xiao16Lin Liu17Lin Liu18Lin Liu19School of Stomatology, Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital, Southwest Medical University, Luzhou, ChinaLuzhou Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Southwest Medical University, Luzhou, ChinaSchool of Stomatology, Southwest Medical University, Luzhou, Sichuan, ChinaKey Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, ChinaDepartment of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital, Southwest Medical University, Luzhou, ChinaLuzhou Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Southwest Medical University, Luzhou, ChinaSchool of Stomatology, Southwest Medical University, Luzhou, Sichuan, ChinaSchool of Stomatology, Southwest Medical University, Luzhou, Sichuan, ChinaSchool of Stomatology, Southwest Medical University, Luzhou, Sichuan, ChinaSchool of Stomatology, Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital, Southwest Medical University, Luzhou, ChinaLuzhou Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Southwest Medical University, Luzhou, ChinaSchool of Stomatology, Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital, Southwest Medical University, Luzhou, ChinaLuzhou Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Southwest Medical University, Luzhou, ChinaSchool of Stomatology, Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital, Southwest Medical University, Luzhou, ChinaLuzhou Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Southwest Medical University, Luzhou, ChinaBackgroundHead and neck squamous cell carcinoma (HNSCC) is the most common type of head and neck cancer and is characterized by its aggressive nature and variable prognosis and response to immunotherapy. Tertiary lymphoid structures (TLSs) play crucial roles in creating a favourable immune microenvironment to control tumour progression. However, the specific impact of these structures on HNSCC has not been thoroughly studied.MethodsIn this study, a comprehensive review of tertiary lymphoid structures was conducted by analysing 9 TLS-associated genes in a cohort of 871 HNSCC patients. Distinct TLS-related subgroups were identified through unsupervised clustering analysis, and the associated genes were explored. Prognostic genes were identified via univariate Cox and Boruta algorithms, and a novel TLS-related scoring system was developed via the GSVA algorithm.ResultsOur study revealed that patients with higher TLS-related scores had improved overall survival and were more likely to benefit from immunotherapy. Furthermore, we observed a significant negative correlation between sensitivity to traditional chemotherapeutic agents and the TLS-related signature score.ConclusionsOur findings suggest that the TLS-related features of HNSCC patients hold promise as predictive indicators for immunotherapy efficacy and may offer novel insights for tailoring personalized treatment strategies in clinical practice.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1551844/fulltertiary lymphatic structureHNSCCGSVAtumour microenvironmentimmunotherapynomogram |
| spellingShingle | Jinhao Zhang Lu Zeng Lu Zeng Guobin Song Gaoge Peng Gaoge Peng Zhezheng Chen Zhezheng Chen Yamin Yuan Taowu Chen Tao Zhong Shixi Chen Zhengzhou Luo Zhengzhou Luo Jingang Xiao Jingang Xiao Jingang Xiao Lin Liu Lin Liu Lin Liu A novel tertiary lymphoid structure-associated signature accurately predicts patient prognosis and facilitates the selection of personalized treatment strategies for HNSCC Frontiers in Immunology tertiary lymphatic structure HNSCC GSVA tumour microenvironment immunotherapy nomogram |
| title | A novel tertiary lymphoid structure-associated signature accurately predicts patient prognosis and facilitates the selection of personalized treatment strategies for HNSCC |
| title_full | A novel tertiary lymphoid structure-associated signature accurately predicts patient prognosis and facilitates the selection of personalized treatment strategies for HNSCC |
| title_fullStr | A novel tertiary lymphoid structure-associated signature accurately predicts patient prognosis and facilitates the selection of personalized treatment strategies for HNSCC |
| title_full_unstemmed | A novel tertiary lymphoid structure-associated signature accurately predicts patient prognosis and facilitates the selection of personalized treatment strategies for HNSCC |
| title_short | A novel tertiary lymphoid structure-associated signature accurately predicts patient prognosis and facilitates the selection of personalized treatment strategies for HNSCC |
| title_sort | novel tertiary lymphoid structure associated signature accurately predicts patient prognosis and facilitates the selection of personalized treatment strategies for hnscc |
| topic | tertiary lymphatic structure HNSCC GSVA tumour microenvironment immunotherapy nomogram |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1551844/full |
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