Gemcitabine–oxaliplatin as a bridge therapy toward autologous hematopoietic stem cell transplantation in infant-type brain tumors

Gemcitabine–oxaliplatin as a bridge therapy toward autologous hematopoietic stem cell transplantation in infant-type brain tumors

IntroductionIn neuro-oncological pediatric patients under 3 years of age, chemotherapy intensified to high doses (high-dose chemotherapy, HDC) represents the cornerstone to avoid the potential toxicity of radiotherapy. Combination treatment with gemcitabine–oxaliplatin (GemOx) was administered for i...

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Main Authors: Barbara Castelli, Carla Fonte, Marco Tellini, Marco Di Nicola, Milena Guidi, Laura Giunti, Bianca Tirinnanzi, Chiara Marzano, Anna Maria Buccoliero, Ludovico D’Incerti, Flavio Giordano, Mirko Scagnet, Veronica Tintori, Lorenzo Genitori, Iacopo Sardi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Oncology
Subjects:
brain tumors
gemcitabine
oxaliplatin
high-dose chemotherapy
autologous stem cell transplantation
pediatric oncology
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1476411/full
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