Hesperidoside abolishes dichlorvos-mediated neurotoxicity in rats by suppressing oxidative stress, acetylcholinesterase inhibition, and NF-κB-p65/p53/caspase-3-mediated apoptosis
Background: In third-world countries, poisoning due to dichlorvos (DDVP), an organophosphate insecticide, is prevalent due to its widespread usage in household and agriculture, with the brain bearing the brunt of the consequences. Hence, this study assessed the likely beneficial impact of hesperidos...
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Elsevier
2025-02-01
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| Series: | Phytomedicine Plus |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667031324001751 |
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| author | Adio J. Akamo Adetutu O. Ojelabi Oluwatobi T. Somade Iyabode A. Kehinde Adewale M. Taiwo Boluwatife A. Olagunju Mushafau A. Akinsanya Adedayo A. Adebisi Tobi S. Adekunbi Abiola F. Adenowo Florence Anifowose Olufemi M. Ajagun-Ogunleye Ofem E. Eteng Jacob K. Akintunde Regina N. Ugbaja |
| author_facet | Adio J. Akamo Adetutu O. Ojelabi Oluwatobi T. Somade Iyabode A. Kehinde Adewale M. Taiwo Boluwatife A. Olagunju Mushafau A. Akinsanya Adedayo A. Adebisi Tobi S. Adekunbi Abiola F. Adenowo Florence Anifowose Olufemi M. Ajagun-Ogunleye Ofem E. Eteng Jacob K. Akintunde Regina N. Ugbaja |
| author_sort | Adio J. Akamo |
| collection | DOAJ |
| description | Background: In third-world countries, poisoning due to dichlorvos (DDVP), an organophosphate insecticide, is prevalent due to its widespread usage in household and agriculture, with the brain bearing the brunt of the consequences. Hence, this study assessed the likely beneficial impact of hesperidoside (HESP) on the DDVP-mediated cerebral dysfunction in rat model. Method: Randomization was employed to earmark forty-two rats into seven groups: control, DDVP alone (8 mg.kg⁻¹day⁻¹), DDVP plus HESP (50 and 100 mg.kg⁻¹day⁻¹) and reference drug atropine (0.2 mg.kg⁻¹day⁻¹), and HESP alone (50 and 100 mg.kg⁻¹day⁻¹). Results: HESP intervention remarkably (p < 0.05) mitigated DDVP-potentiated augmentations in cerebral concentrations of H₂O₂, NO, and malondialdehyde; impaired DDVP-induced decrease in cerebral GSH, GST, SOD, catalase, glutathione peroxidase, and acetylcholinesterase; significantly (p < 0.05) suppressed DDVP-invoked upregulation of mRNA expression of NF-κB-p65, p53, BAX, caspase-3, and TNF-α; and significantly (p < 0.05) revoked DDVP-incited downregulation of interleukin-10. Conclusion: HESP chemotherapeutic interventions enhanced cerebral functions in DDVP-treated rats by abrogating oxidative stress, acetylcholinesterase inhibition, and NF-κB-p65/p53/caspases-3 signaling. |
| format | Article |
| id | doaj-art-024d72324e5a443f86635eada73a1241 |
| institution | Kabale University |
| issn | 2667-0313 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Phytomedicine Plus |
| spelling | doaj-art-024d72324e5a443f86635eada73a12412025-02-10T04:35:10ZengElsevierPhytomedicine Plus2667-03132025-02-0151100701Hesperidoside abolishes dichlorvos-mediated neurotoxicity in rats by suppressing oxidative stress, acetylcholinesterase inhibition, and NF-κB-p65/p53/caspase-3-mediated apoptosisAdio J. Akamo0Adetutu O. Ojelabi1Oluwatobi T. Somade2Iyabode A. Kehinde3Adewale M. Taiwo4Boluwatife A. Olagunju5Mushafau A. Akinsanya6Adedayo A. Adebisi7Tobi S. Adekunbi8Abiola F. Adenowo9Florence Anifowose10Olufemi M. Ajagun-Ogunleye11Ofem E. Eteng12Jacob K. Akintunde13Regina N. Ugbaja14Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Lagos State University College of Medicine, Ikeja, Lagos State, Nigeria; Clinical Biochemistry and Mechanistic Toxicology Research Cluster, Department of Biochemistry, Federal University of Agriculture, Abeokuta, Ogun State, Nigeria; Corresponding authors.Clinical Biochemistry and Mechanistic Toxicology Research Cluster, Department of Biochemistry, Federal University of Agriculture, Abeokuta, Ogun State, NigeriaClinical Biochemistry and Mechanistic Toxicology Research Cluster, Department of Biochemistry, Federal University of Agriculture, Abeokuta, Ogun State, Nigeria; Corresponding authors.Department of Pure and Applied Botany, Federal University of Agriculture, Abeokuta, Ogun State, NigeriaDepartment of Environmental Management and Toxicology, Federal University of Agriculture, Abeokuta, Ogun State, NigeriaClinical Biochemistry and Mechanistic Toxicology Research Cluster, Department of Biochemistry, Federal University of Agriculture, Abeokuta, Ogun State, NigeriaDepartment of Medical Biochemistry, Faculty of Basic Medical Sciences, Lagos State University College of Medicine, Ikeja, Lagos State, NigeriaDepartment of Medical Biochemistry, Faculty of Basic Medical Sciences, Lagos State University College of Medicine, Ikeja, Lagos State, NigeriaDepartment of Medical Biochemistry, Faculty of Basic Medical Sciences, Lagos State University College of Medicine, Ikeja, Lagos State, NigeriaDepartment of Medical Biochemistry, Faculty of Basic Medical Sciences, Lagos State University College of Medicine, Ikeja, Lagos State, NigeriaDepartment of Medical Biochemistry, Faculty of Basic Medical Sciences, Lagos State University College of Medicine, Ikeja, Lagos State, NigeriaDepartment of Medical Biochemistry, Faculty of Basic Medical Sciences, Lagos State University College of Medicine, Ikeja, Lagos State, NigeriaClinical Biochemistry and Mechanistic Toxicology Research Cluster, Department of Biochemistry, Federal University of Agriculture, Abeokuta, Ogun State, NigeriaClinical Biochemistry and Mechanistic Toxicology Research Cluster, Department of Biochemistry, Federal University of Agriculture, Abeokuta, Ogun State, NigeriaClinical Biochemistry and Mechanistic Toxicology Research Cluster, Department of Biochemistry, Federal University of Agriculture, Abeokuta, Ogun State, NigeriaBackground: In third-world countries, poisoning due to dichlorvos (DDVP), an organophosphate insecticide, is prevalent due to its widespread usage in household and agriculture, with the brain bearing the brunt of the consequences. Hence, this study assessed the likely beneficial impact of hesperidoside (HESP) on the DDVP-mediated cerebral dysfunction in rat model. Method: Randomization was employed to earmark forty-two rats into seven groups: control, DDVP alone (8 mg.kg⁻¹day⁻¹), DDVP plus HESP (50 and 100 mg.kg⁻¹day⁻¹) and reference drug atropine (0.2 mg.kg⁻¹day⁻¹), and HESP alone (50 and 100 mg.kg⁻¹day⁻¹). Results: HESP intervention remarkably (p < 0.05) mitigated DDVP-potentiated augmentations in cerebral concentrations of H₂O₂, NO, and malondialdehyde; impaired DDVP-induced decrease in cerebral GSH, GST, SOD, catalase, glutathione peroxidase, and acetylcholinesterase; significantly (p < 0.05) suppressed DDVP-invoked upregulation of mRNA expression of NF-κB-p65, p53, BAX, caspase-3, and TNF-α; and significantly (p < 0.05) revoked DDVP-incited downregulation of interleukin-10. Conclusion: HESP chemotherapeutic interventions enhanced cerebral functions in DDVP-treated rats by abrogating oxidative stress, acetylcholinesterase inhibition, and NF-κB-p65/p53/caspases-3 signaling.http://www.sciencedirect.com/science/article/pii/S2667031324001751HesperidosideDichlorvosNeurotoxicityAcetylcholinesterase inhibitionOxidative damageInflammation |
| spellingShingle | Adio J. Akamo Adetutu O. Ojelabi Oluwatobi T. Somade Iyabode A. Kehinde Adewale M. Taiwo Boluwatife A. Olagunju Mushafau A. Akinsanya Adedayo A. Adebisi Tobi S. Adekunbi Abiola F. Adenowo Florence Anifowose Olufemi M. Ajagun-Ogunleye Ofem E. Eteng Jacob K. Akintunde Regina N. Ugbaja Hesperidoside abolishes dichlorvos-mediated neurotoxicity in rats by suppressing oxidative stress, acetylcholinesterase inhibition, and NF-κB-p65/p53/caspase-3-mediated apoptosis Phytomedicine Plus Hesperidoside Dichlorvos Neurotoxicity Acetylcholinesterase inhibition Oxidative damage Inflammation |
| title | Hesperidoside abolishes dichlorvos-mediated neurotoxicity in rats by suppressing oxidative stress, acetylcholinesterase inhibition, and NF-κB-p65/p53/caspase-3-mediated apoptosis |
| title_full | Hesperidoside abolishes dichlorvos-mediated neurotoxicity in rats by suppressing oxidative stress, acetylcholinesterase inhibition, and NF-κB-p65/p53/caspase-3-mediated apoptosis |
| title_fullStr | Hesperidoside abolishes dichlorvos-mediated neurotoxicity in rats by suppressing oxidative stress, acetylcholinesterase inhibition, and NF-κB-p65/p53/caspase-3-mediated apoptosis |
| title_full_unstemmed | Hesperidoside abolishes dichlorvos-mediated neurotoxicity in rats by suppressing oxidative stress, acetylcholinesterase inhibition, and NF-κB-p65/p53/caspase-3-mediated apoptosis |
| title_short | Hesperidoside abolishes dichlorvos-mediated neurotoxicity in rats by suppressing oxidative stress, acetylcholinesterase inhibition, and NF-κB-p65/p53/caspase-3-mediated apoptosis |
| title_sort | hesperidoside abolishes dichlorvos mediated neurotoxicity in rats by suppressing oxidative stress acetylcholinesterase inhibition and nf κb p65 p53 caspase 3 mediated apoptosis |
| topic | Hesperidoside Dichlorvos Neurotoxicity Acetylcholinesterase inhibition Oxidative damage Inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S2667031324001751 |
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