Targeting cuproptosis with nano material: new way to enhancing the efficacy of immunotherapy in colorectal cancer
Colorectal cancer has emerged as one of the predominant malignant tumors globally. Immunotherapy, as a novel therapeutic methodology, has opened up new possibilities for colorectal cancer patients. However, its actual clinical efficacy requires further enhancement. Copper, as an exceptionally crucia...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1451067/full |
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| author | Xiangdong Liu Xiangdong Liu Xiangdong Liu Wanqiu Zhang Wanqiu Zhang Wanqiu Zhang Shaozhong Wei Shaozhong Wei Shaozhong Wei Xinjun Liang Xinjun Liang Xinjun Liang Bo Luo Bo Luo Bo Luo |
| author_facet | Xiangdong Liu Xiangdong Liu Xiangdong Liu Wanqiu Zhang Wanqiu Zhang Wanqiu Zhang Shaozhong Wei Shaozhong Wei Shaozhong Wei Xinjun Liang Xinjun Liang Xinjun Liang Bo Luo Bo Luo Bo Luo |
| author_sort | Xiangdong Liu |
| collection | DOAJ |
| description | Colorectal cancer has emerged as one of the predominant malignant tumors globally. Immunotherapy, as a novel therapeutic methodology, has opened up new possibilities for colorectal cancer patients. However, its actual clinical efficacy requires further enhancement. Copper, as an exceptionally crucial trace element, can influence various signaling pathways, gene expression, and biological metabolic processes in cells, thus playing a critical role in the pathogenesis of colorectal cancer. Recent studies have revealed that cuproptosis, a novel mode of cell death, holds promise to become a potential target to overcome resistance to colorectal cancer immunotherapy. This shows substantial potential in the combination treatment of colorectal cancer. Conveying copper into tumor cells via a nano-drug delivery system to induce cuproptosis of colorectal cancer cells could offer a potential strategy for eliminating drug-resistant colorectal cancer cells and vastly improving the efficacy of immunotherapy while ultimately destroy colorectal tumors. Moreover, combining the cuproptosis induction strategy with other anti-tumor approaches such as photothermal therapy, photodynamic therapy, and chemodynamic therapy could further enhance its therapeutic effect. This review aims to illuminate the practical significance of cuproptosis and cuproptosis-inducing nano-drugs in colorectal cancer immunotherapy, and scrutinize the current challenges and limitations of this methodology, thereby providing innovative thoughts and references for the advancement of cuproptosis-based colorectal cancer immunotherapy strategies. |
| format | Article |
| id | doaj-art-024c0ea044c443e7ae7a0e8375fd4daf |
| institution | OA Journals |
| issn | 1663-9812 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-024c0ea044c443e7ae7a0e8375fd4daf2025-08-20T02:38:29ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-12-011510.3389/fphar.2024.14510671451067Targeting cuproptosis with nano material: new way to enhancing the efficacy of immunotherapy in colorectal cancerXiangdong Liu0Xiangdong Liu1Xiangdong Liu2Wanqiu Zhang3Wanqiu Zhang4Wanqiu Zhang5Shaozhong Wei6Shaozhong Wei7Shaozhong Wei8Xinjun Liang9Xinjun Liang10Xinjun Liang11Bo Luo12Bo Luo13Bo Luo14Department of Radiotherapy Center, Hubei Cancer Hospital, The Seventh Clinical School Affiliated of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Provincial Clinical Research Center for Colorectal Cancer, Wuhan, ChinaWuhan Clinical Research Center for Colorectal Cancer, Wuhan, ChinaDepartment of Radiotherapy Center, Hubei Cancer Hospital, The Seventh Clinical School Affiliated of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Provincial Clinical Research Center for Colorectal Cancer, Wuhan, ChinaWuhan Clinical Research Center for Colorectal Cancer, Wuhan, ChinaHubei Provincial Clinical Research Center for Colorectal Cancer, Wuhan, ChinaWuhan Clinical Research Center for Colorectal Cancer, Wuhan, ChinaDepartment of Gastrointestinal Oncology Surgery, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Provincial Clinical Research Center for Colorectal Cancer, Wuhan, ChinaWuhan Clinical Research Center for Colorectal Cancer, Wuhan, ChinaDepartment of Abdominal Oncology, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Radiotherapy Center, Hubei Cancer Hospital, The Seventh Clinical School Affiliated of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Provincial Clinical Research Center for Colorectal Cancer, Wuhan, ChinaWuhan Clinical Research Center for Colorectal Cancer, Wuhan, ChinaColorectal cancer has emerged as one of the predominant malignant tumors globally. Immunotherapy, as a novel therapeutic methodology, has opened up new possibilities for colorectal cancer patients. However, its actual clinical efficacy requires further enhancement. Copper, as an exceptionally crucial trace element, can influence various signaling pathways, gene expression, and biological metabolic processes in cells, thus playing a critical role in the pathogenesis of colorectal cancer. Recent studies have revealed that cuproptosis, a novel mode of cell death, holds promise to become a potential target to overcome resistance to colorectal cancer immunotherapy. This shows substantial potential in the combination treatment of colorectal cancer. Conveying copper into tumor cells via a nano-drug delivery system to induce cuproptosis of colorectal cancer cells could offer a potential strategy for eliminating drug-resistant colorectal cancer cells and vastly improving the efficacy of immunotherapy while ultimately destroy colorectal tumors. Moreover, combining the cuproptosis induction strategy with other anti-tumor approaches such as photothermal therapy, photodynamic therapy, and chemodynamic therapy could further enhance its therapeutic effect. This review aims to illuminate the practical significance of cuproptosis and cuproptosis-inducing nano-drugs in colorectal cancer immunotherapy, and scrutinize the current challenges and limitations of this methodology, thereby providing innovative thoughts and references for the advancement of cuproptosis-based colorectal cancer immunotherapy strategies.https://www.frontiersin.org/articles/10.3389/fphar.2024.1451067/fullcolorectal cancercuproptosisimmunotherapynanoparticletargeted therapy |
| spellingShingle | Xiangdong Liu Xiangdong Liu Xiangdong Liu Wanqiu Zhang Wanqiu Zhang Wanqiu Zhang Shaozhong Wei Shaozhong Wei Shaozhong Wei Xinjun Liang Xinjun Liang Xinjun Liang Bo Luo Bo Luo Bo Luo Targeting cuproptosis with nano material: new way to enhancing the efficacy of immunotherapy in colorectal cancer Frontiers in Pharmacology colorectal cancer cuproptosis immunotherapy nanoparticle targeted therapy |
| title | Targeting cuproptosis with nano material: new way to enhancing the efficacy of immunotherapy in colorectal cancer |
| title_full | Targeting cuproptosis with nano material: new way to enhancing the efficacy of immunotherapy in colorectal cancer |
| title_fullStr | Targeting cuproptosis with nano material: new way to enhancing the efficacy of immunotherapy in colorectal cancer |
| title_full_unstemmed | Targeting cuproptosis with nano material: new way to enhancing the efficacy of immunotherapy in colorectal cancer |
| title_short | Targeting cuproptosis with nano material: new way to enhancing the efficacy of immunotherapy in colorectal cancer |
| title_sort | targeting cuproptosis with nano material new way to enhancing the efficacy of immunotherapy in colorectal cancer |
| topic | colorectal cancer cuproptosis immunotherapy nanoparticle targeted therapy |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1451067/full |
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