The role of LGR4 in bone metabolism and tumor bone metastasis
The Leucine-rich repeat-containing G protein-coupled receptor 4 (LGR4) is a member of the G protein-coupled receptor family and plays an important role in bone metabolism and tumor bone metastasis. LGR4 affects bone metabolism by regulating the differentiation and activity of osteoblasts and osteocl...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1541601/full |
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| _version_ | 1850128405226323968 |
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| author | Jiawang Huang Yucheng Jin Zhigang Yi |
| author_facet | Jiawang Huang Yucheng Jin Zhigang Yi |
| author_sort | Jiawang Huang |
| collection | DOAJ |
| description | The Leucine-rich repeat-containing G protein-coupled receptor 4 (LGR4) is a member of the G protein-coupled receptor family and plays an important role in bone metabolism and tumor bone metastasis. LGR4 affects bone metabolism by regulating the differentiation and activity of osteoblasts and osteoclasts, and is involved in the balance between bone resorption and bone formation. Deficiency of LGR4 leads to osteoporosis, whereas the up-regulation of LGR4 may help to alleviate the development of traumatic osteoarthritis. Furthermore, in breast cancer and multiple myeloma, LGR4 promotes tumor cell metastasis to bone tissue by activating related signaling pathways. Therefore, LGR4 may be a potential target for the treatment of bone metabolic diseases and tumor bone metastasis. |
| format | Article |
| id | doaj-art-0249e8686f274971a0c8289dd8e808ca |
| institution | OA Journals |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-0249e8686f274971a0c8289dd8e808ca2025-08-20T02:33:19ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-05-011610.3389/fendo.2025.15416011541601The role of LGR4 in bone metabolism and tumor bone metastasisJiawang Huang0Yucheng Jin1Zhigang Yi2The Second Medical College of Lanzhou University, Lanzhou, ChinaThe Second Medical College of Lanzhou University, Lanzhou, ChinaLanzhou University Second Hospital, Lanzhou, ChinaThe Leucine-rich repeat-containing G protein-coupled receptor 4 (LGR4) is a member of the G protein-coupled receptor family and plays an important role in bone metabolism and tumor bone metastasis. LGR4 affects bone metabolism by regulating the differentiation and activity of osteoblasts and osteoclasts, and is involved in the balance between bone resorption and bone formation. Deficiency of LGR4 leads to osteoporosis, whereas the up-regulation of LGR4 may help to alleviate the development of traumatic osteoarthritis. Furthermore, in breast cancer and multiple myeloma, LGR4 promotes tumor cell metastasis to bone tissue by activating related signaling pathways. Therefore, LGR4 may be a potential target for the treatment of bone metabolic diseases and tumor bone metastasis.https://www.frontiersin.org/articles/10.3389/fendo.2025.1541601/fullLGR4bone metabolismbone metastasisosteoclastsosteoblasts |
| spellingShingle | Jiawang Huang Yucheng Jin Zhigang Yi The role of LGR4 in bone metabolism and tumor bone metastasis Frontiers in Endocrinology LGR4 bone metabolism bone metastasis osteoclasts osteoblasts |
| title | The role of LGR4 in bone metabolism and tumor bone metastasis |
| title_full | The role of LGR4 in bone metabolism and tumor bone metastasis |
| title_fullStr | The role of LGR4 in bone metabolism and tumor bone metastasis |
| title_full_unstemmed | The role of LGR4 in bone metabolism and tumor bone metastasis |
| title_short | The role of LGR4 in bone metabolism and tumor bone metastasis |
| title_sort | role of lgr4 in bone metabolism and tumor bone metastasis |
| topic | LGR4 bone metabolism bone metastasis osteoclasts osteoblasts |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1541601/full |
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