Clonal hematopoiesis of indeterminate potential and heart failure
Modern studies demonstrate that clonal hematopoiesis of indeterminate potential (CHIP) is a risk factor for the development and prognosis of heart failure (HF) of various origin. The pathophysiology and consequences of CHIP are gene-specific. The mechanisms involved in this process are complex and i...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2024-12-01
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| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/6016 |
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| author | E. A. Lyasnikova L. Yu Ivanchenko S. N. Kozlova M. Yu. SITNIKOVA A. A. Kostareva E. V. Shlyakhto |
| author_facet | E. A. Lyasnikova L. Yu Ivanchenko S. N. Kozlova M. Yu. SITNIKOVA A. A. Kostareva E. V. Shlyakhto |
| author_sort | E. A. Lyasnikova |
| collection | DOAJ |
| description | Modern studies demonstrate that clonal hematopoiesis of indeterminate potential (CHIP) is a risk factor for the development and prognosis of heart failure (HF) of various origin. The pathophysiology and consequences of CHIP are gene-specific. The mechanisms involved in this process are complex and indicate the central role of systemic and myocardial inflammation, including the immune response dependent on the inflammasome/interleukin-1β/interleukin-6 cascade. CHIP and associated inflammatory pathways represent a powerful potential target, which rationales the research in the area of various HF stages and markers of this genetic phenomenon. A better understanding of the interactions between mutant clones, immune pathways, chronic inflammation and clinical implementation in HF may be important in the context of precision and personalized medicine. |
| format | Article |
| id | doaj-art-0245766a2df646799b50d89bbdf0f6d8 |
| institution | DOAJ |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2024-12-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-0245766a2df646799b50d89bbdf0f6d82025-08-20T03:01:27Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202024-12-012911S10.15829/1560-4071-2024-60164168Clonal hematopoiesis of indeterminate potential and heart failureE. A. Lyasnikova0L. Yu Ivanchenko1S. N. Kozlova2M. Yu. SITNIKOVA3A. A. Kostareva4E. V. Shlyakhto5Almazov National Medical Research CenterAlmazov National Medical Research CenterAlmazov National Medical Research CenterAlmazov National Medical Research CenterAlmazov National Medical Research CenterAlmazov National Medical Research CenterModern studies demonstrate that clonal hematopoiesis of indeterminate potential (CHIP) is a risk factor for the development and prognosis of heart failure (HF) of various origin. The pathophysiology and consequences of CHIP are gene-specific. The mechanisms involved in this process are complex and indicate the central role of systemic and myocardial inflammation, including the immune response dependent on the inflammasome/interleukin-1β/interleukin-6 cascade. CHIP and associated inflammatory pathways represent a powerful potential target, which rationales the research in the area of various HF stages and markers of this genetic phenomenon. A better understanding of the interactions between mutant clones, immune pathways, chronic inflammation and clinical implementation in HF may be important in the context of precision and personalized medicine.https://russjcardiol.elpub.ru/jour/article/view/6016heart failureclonal hematopoiesis of indeterminate potentialinflammation |
| spellingShingle | E. A. Lyasnikova L. Yu Ivanchenko S. N. Kozlova M. Yu. SITNIKOVA A. A. Kostareva E. V. Shlyakhto Clonal hematopoiesis of indeterminate potential and heart failure Российский кардиологический журнал heart failure clonal hematopoiesis of indeterminate potential inflammation |
| title | Clonal hematopoiesis of indeterminate potential and heart failure |
| title_full | Clonal hematopoiesis of indeterminate potential and heart failure |
| title_fullStr | Clonal hematopoiesis of indeterminate potential and heart failure |
| title_full_unstemmed | Clonal hematopoiesis of indeterminate potential and heart failure |
| title_short | Clonal hematopoiesis of indeterminate potential and heart failure |
| title_sort | clonal hematopoiesis of indeterminate potential and heart failure |
| topic | heart failure clonal hematopoiesis of indeterminate potential inflammation |
| url | https://russjcardiol.elpub.ru/jour/article/view/6016 |
| work_keys_str_mv | AT ealyasnikova clonalhematopoiesisofindeterminatepotentialandheartfailure AT lyuivanchenko clonalhematopoiesisofindeterminatepotentialandheartfailure AT snkozlova clonalhematopoiesisofindeterminatepotentialandheartfailure AT myusitnikova clonalhematopoiesisofindeterminatepotentialandheartfailure AT aakostareva clonalhematopoiesisofindeterminatepotentialandheartfailure AT evshlyakhto clonalhematopoiesisofindeterminatepotentialandheartfailure |