In silico evaluation of the immunogenic profile of lung cancers with SMARCA4 genetic alterations

In silico evaluation of the immunogenic profile of lung cancers with SMARCA4 genetic alterations

Abstract Genomic alterations in tumor cells can influence immune response, as has been demonstrated in several tumor types. For instance, mutations in certain genes like EGFR or B-RAF are associated with a particular immune phenotype. Non-small cell lung cancer (NSCLC) is one of the most immunogenic...

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Main Authors: Cristina Nieto-Jiménez, Esther Garcia-Lorenzo, Cristina Diaz-Tejeiro, Lucía Paniagua-Herranz, Adrián Sanvicente, Bernard Doger, Irene Moreno, Manuel Pedregal, Jorge Bartolomé, Arancha Manzano, Gyöngyi Munkácsy, Balázs Győrffy, Pedro Pérez-Segura, Emiliano Calvo, Victor Moreno, Alberto Ocana
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Lung adenocarcinoma
LUAD
SMARCA4
Immune response
Immunologic profile
Online Access:https://doi.org/10.1038/s41598-025-02494-x
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