Aging-associated DNA methylation of LEF1 modulates inflammation and neurodegenerative pathways

Aging-associated DNA methylation of LEF1 modulates inflammation and neurodegenerative pathways

BackgroundAging is accompanied by profound changes in immune regulation and epigenetic landscapes, yet the molecular drivers underlying these alterations are not fully understood.MethodsTranscriptional profiles of peripheral blood samples from young and elderly individuals, together with aging-assoc...

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Bibliographic Details
Main Authors:	Mengke Chen, Lujie Zhou, Yidan Gao, Yao Zhong, Cheng Chen, Zhicheng Wang, Xiaoning Wang, Rong Xia
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-08-01
Series:	Frontiers in Immunology
Subjects:	aging DNA methylation inflammation LEF1 microglia
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1656442/full
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