Dynamic Brain Lipid Profiles Modulate Microglial Lipid Droplet Accumulation and Inflammation Under Ischemic Conditions in Mice

Dynamic Brain Lipid Profiles Modulate Microglial Lipid Droplet Accumulation and Inflammation Under Ischemic Conditions in Mice

Abstract Microglia are critically involved in post‐stroke inflammation affecting neurological outcomes. Lipid droplet (LD) accumulation in microglia results in a dysfunctional and pro‐inflammatory state in the aged brain and worsens the outcome of neuroinflammatory and neurodegenerative diseases. Ho...

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Main Authors: Wei Wei, Seyed Siyawasch Justus Lattau, Wenqiang Xin, Yongli Pan, Lars Tatenhorst, Lin Zhang, Irina Graf, Yaoyun Kuang, Xuan Zheng, Zhongnan Hao, Aurel Popa‐Wagner, Stefan T. Gerner, Sabine Huber, Manuel Nietert, Christian Klose, Ertugrul Kilic, Dirk M. Hermann, Mathias Bähr, Hagen B. Huttner, Hua Liu, Dirk Fitzner, Thorsten R. Doeppner
Format: Article
Language:English
Published: Wiley 2024-11-01
Series:Advanced Science
Subjects:
cholesterol metabolism
ischemic stroke
lipid droplets
lipid metabolism
lipidomics
microglia
Online Access:https://doi.org/10.1002/advs.202306863
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