Stress-dependent activation of the Listeria monocytogenes virulence program ensures bacterial resilience during infection

Stress-dependent activation of the Listeria monocytogenes virulence program ensures bacterial resilience during infection

ABSTRACT Listeria monocytogenes (Lm) is a Gram-positive, facultative intracellular pathogen that uses both a housekeeping (P1) and stress-activated (Sigma B-dependent) promoter (P2) to express the master virulence regulator PrfA. The Sigma B regulon contains over 300 genes known to respond to differ...

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Bibliographic Details
Main Authors: Mariya Lobanovska, Ying Feng, Jonathan Zhang, Allison H. Williams, Daniel A. Portnoy
Format: Article
Language:English
Published: American Society for Microbiology 2025-06-01
Series:mBio
Subjects:
intracellular bacteria
pathogenesis
stress adaptation
sigma factors
virulence regulation
macrophages
Online Access:https://journals.asm.org/doi/10.1128/mbio.00719-25
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