Evidence of Zika virus circulation in human and livestock in Chad
Zika virus (ZIKV) is a major public health problem worldwide. After several reported outbreaks, the current extent of infections caused by this orthoflavivirus in the Sahel remains to be explored. We investigated the prevalence of neutralizing antibodies against ZIKV in the general population, in HI...
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| Language: | English |
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Elsevier
2024-12-01
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| Series: | Virus Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0168170224001850 |
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| author | François Chable de la Héronnière Jonathan Barthelemy Guy R Takoudjou Dzomo Fatima Abdelrazakh Oumaima Djarma Lucas Auguste Abderrazzack A Fouda Chatté Adawaye Laurent Andreoletti Mahamat Fayiz Abakar Yannick Simonin Sara Salinas Franck JD Mennechet |
| author_facet | François Chable de la Héronnière Jonathan Barthelemy Guy R Takoudjou Dzomo Fatima Abdelrazakh Oumaima Djarma Lucas Auguste Abderrazzack A Fouda Chatté Adawaye Laurent Andreoletti Mahamat Fayiz Abakar Yannick Simonin Sara Salinas Franck JD Mennechet |
| author_sort | François Chable de la Héronnière |
| collection | DOAJ |
| description | Zika virus (ZIKV) is a major public health problem worldwide. After several reported outbreaks, the current extent of infections caused by this orthoflavivirus in the Sahel remains to be explored. We investigated the prevalence of neutralizing antibodies against ZIKV in the general population, in HIV-infected individuals and in livestock in Chad using a seroneutralization assay that ensures high specificity level. In this retrospective serological serosurveillance investigation, we estimated the neutralizing seroprevalence to be approximately 26 % (18/69) in healthy Chadian participants and 17 % (16/94) in HIV-infected individuals, with no statistical difference between these two subgroups or genders. In addition, we found an overall ZIKV prevalence of 14 % (8/59) in small ruminants (sheep and goats) living in the Lake Chad Basin area, demonstrating virus circulation in animals. Our pilot study shows for the first-time evidence of ZIKV circulation in humans and in livestock in Chad in close interaction with humans, and highlights the main challenges associated with this virus in Sahelian areas. |
| format | Article |
| id | doaj-art-02329edb2edb4ef48bbe27bd9328430e |
| institution | OA Journals |
| issn | 1872-7492 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Virus Research |
| spelling | doaj-art-02329edb2edb4ef48bbe27bd9328430e2025-08-20T02:34:34ZengElsevierVirus Research1872-74922024-12-0135019949210.1016/j.virusres.2024.199492Evidence of Zika virus circulation in human and livestock in ChadFrançois Chable de la Héronnière0Jonathan Barthelemy1Guy R Takoudjou Dzomo2Fatima Abdelrazakh3Oumaima Djarma4Lucas Auguste5Abderrazzack A Fouda6Chatté Adawaye7Laurent Andreoletti8Mahamat Fayiz Abakar9Yannick Simonin10Sara Salinas11Franck JD Mennechet12Pathogenesis and Control of Chronic and Emerging Infections (PCCEI), INSERM U1058, University of Montpellier, French Blood Establishment (EFS), Montpellier, FrancePathogenesis and Control of Chronic and Emerging Infections (PCCEI), INSERM U1058, University of Montpellier, French Blood Establishment (EFS), Montpellier, FranceUniversity Hospital Complex ''Le Bon Samaritain'', N'Djamena, ChadLivestock Research Institute for Development (IRED), N'Djamena, ChadMinistry of Public Health and Solidarity, N'Djamena, ChadPathogenesis and Control of Chronic and Emerging Infections (PCCEI), INSERM U1058, University of Montpellier, French Blood Establishment (EFS), Montpellier, FranceMinistry of Public Health and Solidarity, N'Djamena, Chad; Toumaï University, N'Djamena, ChadMinistry of Public Health and Solidarity, N'Djamena, Chad; Faculty of Human Health Sciences, N'Djamena, ChadVirology laboratory, Faculty of Medicine, INSERM U1320, University of Reims Champagne Ardennes, and UHC of Reims, France; Academic Hospital of Reims, Robert Debré, Virology Department, Reims, FranceLivestock Research Institute for Development (IRED), N'Djamena, ChadPathogenesis and Control of Chronic and Emerging Infections (PCCEI), INSERM U1058, University of Montpellier, French Blood Establishment (EFS), Montpellier, FrancePathogenesis and Control of Chronic and Emerging Infections (PCCEI), INSERM U1058, University of Montpellier, French Blood Establishment (EFS), Montpellier, FrancePathogenesis and Control of Chronic and Emerging Infections (PCCEI), INSERM U1058, University of Montpellier, French Blood Establishment (EFS), Montpellier, France; Corresponding author at: Pathogenesis and Control of Chronic and Emerging Infections (PCCEI), INSERM U1058, University of Montpellier, French Blood Establishment (EFS), Montpellier, FranceZika virus (ZIKV) is a major public health problem worldwide. After several reported outbreaks, the current extent of infections caused by this orthoflavivirus in the Sahel remains to be explored. We investigated the prevalence of neutralizing antibodies against ZIKV in the general population, in HIV-infected individuals and in livestock in Chad using a seroneutralization assay that ensures high specificity level. In this retrospective serological serosurveillance investigation, we estimated the neutralizing seroprevalence to be approximately 26 % (18/69) in healthy Chadian participants and 17 % (16/94) in HIV-infected individuals, with no statistical difference between these two subgroups or genders. In addition, we found an overall ZIKV prevalence of 14 % (8/59) in small ruminants (sheep and goats) living in the Lake Chad Basin area, demonstrating virus circulation in animals. Our pilot study shows for the first-time evidence of ZIKV circulation in humans and in livestock in Chad in close interaction with humans, and highlights the main challenges associated with this virus in Sahelian areas.http://www.sciencedirect.com/science/article/pii/S0168170224001850Zika virusseroneutralization testChadseroprevalence |
| spellingShingle | François Chable de la Héronnière Jonathan Barthelemy Guy R Takoudjou Dzomo Fatima Abdelrazakh Oumaima Djarma Lucas Auguste Abderrazzack A Fouda Chatté Adawaye Laurent Andreoletti Mahamat Fayiz Abakar Yannick Simonin Sara Salinas Franck JD Mennechet Evidence of Zika virus circulation in human and livestock in Chad Virus Research Zika virus seroneutralization test Chad seroprevalence |
| title | Evidence of Zika virus circulation in human and livestock in Chad |
| title_full | Evidence of Zika virus circulation in human and livestock in Chad |
| title_fullStr | Evidence of Zika virus circulation in human and livestock in Chad |
| title_full_unstemmed | Evidence of Zika virus circulation in human and livestock in Chad |
| title_short | Evidence of Zika virus circulation in human and livestock in Chad |
| title_sort | evidence of zika virus circulation in human and livestock in chad |
| topic | Zika virus seroneutralization test Chad seroprevalence |
| url | http://www.sciencedirect.com/science/article/pii/S0168170224001850 |
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